Department of Molecular Genetics and Microbiology, Center for Microbial Pathogenesis, Duke University Medical Center, Durham, NC 27710, USA.
Cold Spring Harb Perspect Med. 2013 May 1;3(5):a010256. doi: 10.1101/cshperspect.a010256.
Chlamydia trachomatis is the most common sexually transmitted bacterial pathogen and the causative agent of blinding trachoma. Although Chlamydia is protected from humoral immune responses by residing within remodeled intracellular vacuoles, it still must contend with multilayered intracellular innate immune defenses deployed by its host while scavenging for nutrients. Here we provide an overview of Chlamydia biology and highlight recent findings detailing how this vacuole-bound pathogen manipulates host-cellular functions to invade host cells and maintain a replicative niche.
沙眼衣原体是最常见的性传播细菌病原体，也是导致致盲性沙眼的病原体。尽管沙眼衣原体寄居在经过重塑的细胞内空泡中，从而免受体液免疫应答的影响，但它在吞噬营养物质的同时，仍必须应对宿主细胞内多层固有免疫防御。本文概述了沙眼衣原体的生物学特性，并重点介绍了最近的研究发现，详细说明了这种局限在空泡内的病原体如何操纵宿主细胞功能来入侵宿主细胞并维持复制生态位。
