Wandinger-Ness Angela, Zerial Marino
Department of Pathology MSC08 4640, University of New Mexico HSC, Albuquerque, New Mexico 87131.
Max Planck Institute of Molecular and Cell Biology and Genetics, 01307 Dresden, Germany.
Cold Spring Harb Perspect Biol. 2014 Oct 23;6(11):a022616. doi: 10.1101/cshperspect.a022616.
Of the approximately 70 human Rab GTPases, nearly three-quarters are involved in endocytic trafficking. Significant plasticity in endosomal membrane transport pathways is closely coupled to receptor signaling and Rab GTPase-regulated scaffolds. Here we review current literature pertaining to endocytic Rab GTPase localizations, functions, and coordination with regulatory proteins and effectors. The roles of Rab GTPases in (1) compartmentalization of the endocytic pathway into early, recycling, late, and lysosomal routes; (2) coordination of individual transport steps from vesicle budding to fusion; (3) effector interactomes; and (4) integration of GTPase and signaling cascades are discussed.
在大约70种人类Rab GTP酶中，近四分之三参与内吞运输。内体膜运输途径的显著可塑性与受体信号传导和Rab GTP酶调节的支架密切相关。在这里，我们综述了有关内吞Rab GTP酶定位、功能以及与调节蛋白和效应器协调的当前文献。讨论了Rab GTP酶在以下方面的作用：（1）将内吞途径划分为早期、循环、晚期和溶酶体途径；（2）协调从囊泡出芽到融合的各个运输步骤；（3）效应器相互作用组；（4）GTP酶和信号级联的整合。
