Suppr超能文献

用于调强放疗治疗中表面剂量测定的光激励发光剂量计(OSLD)及治疗计划系统的验证。

Validation of OSLD and a treatment planning system for surface dose determination in IMRT treatments.

作者信息

Zhuang Audrey H, Olch Arthur J

机构信息

Department of Radiation Oncology, Keck School of Medicine, University of Southern California, Los Angeles, California 90033.

Department of Radiation Oncology, Keck School of Medicine, University of Southern California, Los Angeles, California 90033 and Department of Radiation Oncology, Children's Hospital Los Angeles, Los Angeles, California 90027.

出版信息

Med Phys. 2014 Aug;41(8):081720. doi: 10.1118/1.4890795.

Abstract

PURPOSE

To evaluate the accuracy of skin dose determination for composite multibeam 3D conformal radiation therapy (3DCRT) and intensity modulated radiation therapy (IMRT) treatments using optically stimulated luminescent dosimeters (OSLDs) and Eclipse treatment planning system.

METHODS

Surface doses measured by OSLDs in the buildup region for open field 6 MV beams, either perpendicular or oblique to the surface, were evaluated by comparing against dose measured by Markus Parallel Plate (PP) chamber, surface diodes, and calculated by Monte Carlo simulations. The accuracy of percent depth dose (PDD) calculation in the buildup region from the authors' Eclipse system (Version 10), which was precisely commissioned in the buildup region and was used with 1 mm calculation grid, was also evaluated by comparing to PP chamber measurements and Monte Carlo simulations. Finally, an anthropomorphic pelvic phantom was CT scanned with OSLDs in place at three locations. A planning target volume (PTV) was defined that extended close to the surface. Both an 8 beam 3DCRT and IMRT plan were generated in Eclipse. OSLDs were placed at the CT scanned reference locations to measure the skin doses and were compared to diode measurements and Eclipse calculations. Efforts were made to ensure that the dose comparison was done at the effective measurement points of each detector and corresponding locations in CT images.

RESULTS

The depth of the effective measurement point is 0.8 mm for OSLD when used in the buildup region in a 6 MV beam and is 0.7 mm for the authors' surface diode. OSLDs and Eclipse system both agree well with Monte Carlo and/or Markus PP ion chamber and/or diode in buildup regions in 6 MV beams with normal or oblique incidence and across different field sizes. For the multiple beam 3DCRT plan and IMRT plans, the differences between OSLDs and Eclipse calculations on the surface of the anthropomorphic phantom were within 3% and distance-to-agreement less than 0.3 mm.

CONCLUSIONS

The authors' experiment showed that OSLD is an accurate dosimeter for skin dose measurements in complex 3DCRT or IMRT plans. It also showed that an Eclipse system with accurate commissioning of the data in the buildup region and 1 mm calculation grid can calculate surface doses with high accuracy and has a potential to replace in vivo measurements.

摘要

目的

使用光激励发光剂量计(OSLD)和Eclipse治疗计划系统,评估复合多束三维适形放射治疗(3DCRT)和调强放射治疗(IMRT)中皮肤剂量测定的准确性。

方法

通过将OSLD在开放野6 MV射束的建成区中测量的表面剂量(射束垂直或倾斜于表面)与Markus平行板(PP)电离室、表面二极管测量的剂量以及通过蒙特卡罗模拟计算的剂量进行比较来评估。还通过与PP电离室测量值和蒙特卡罗模拟进行比较,评估了作者的Eclipse系统(版本10)在建成区精确调试并使用1 mm计算网格时在建成区中百分深度剂量(PDD)计算的准确性。最后,对一个带有OSLD的人体盆腔模体在三个位置进行CT扫描。定义了一个靠近表面延伸的计划靶区(PTV)。在Eclipse中生成了一个8束3DCRT计划和一个IMRT计划。将OSLD放置在CT扫描的参考位置以测量皮肤剂量,并与二极管测量值和Eclipse计算值进行比较。努力确保在每个探测器的有效测量点以及CT图像中的相应位置进行剂量比较。

结果

当在6 MV射束的建成区中使用时,OSLD的有效测量点深度为0.8 mm,作者的表面二极管为0.7 mm。在6 MV射束的建成区中,对于垂直或倾斜入射以及不同射野大小,OSLD和Eclipse系统与蒙特卡罗和/或Markus PP电离室和/或二极管的结果都吻合良好。对于多束3DCRT计划和IMRT计划,人体模体表面上OSLD测量值与Eclipse计算值之间的差异在3%以内,一致性距离小于0.3 mm。

结论

作者的实验表明,OSLD是用于复杂3DCRT或IMRT计划中皮肤剂量测量的准确剂量计。还表明,在建成区对数据进行精确调试并使用1 mm计算网格的Eclipse系统能够高精度地计算表面剂量,并且有潜力替代体内测量。

文献AI研究员

20分钟写一篇综述,助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型,支持多种主流文档格式。

立即体验