Malagelada J R, Longstreth G F, Summerskill W H, Go V L
Gastroenterology. 1976 Feb;70(2):203-10.
A method of measuring gastric secretions and emptying rates after ingestion of an ordinary (solid-liquid) meal has been developed and validated. The technique quantifies movements of volume across the pylorus using constant duodenal perfusion with a nonabsorbable marker, polyethylene glycol (PEG), which, in turn, quantifies emptying into the duodenum of another marker, [14C]PEG, incorporated in the meal. Acid and pepsin outputs can be determined without manipulation of the intragastric pH. Employing this method, we have simultaneously quantified acid, pepsin, and total secretory outputs; rates of gastric emptying of meal and secretions; and serum gastrin levels during digestion. These data characterize physiological responses to ordinary food in health.
一种测量摄入普通（固体 - 液体）餐后胃分泌物及排空率的方法已得到开发和验证。该技术使用不可吸收标记物聚乙二醇（PEG）进行持续十二指肠灌注，以此量化通过幽门的体积移动，进而量化餐食中掺入的另一种标记物[14C]PEG排入十二指肠的情况。无需调节胃内pH值即可测定酸和胃蛋白酶的分泌量。采用该方法，我们同时量化了酸、胃蛋白酶和总分泌量；餐食和分泌物的胃排空率；以及消化过程中的血清胃泌素水平。这些数据表征了健康状态下对普通食物的生理反应。
