Dooley C P, Reznick J B, Valenzuela J E
Gastroenterology. 1984 Nov;87(5):1114-9.
The gastric emptying of liquids is determined by the pressure gradient between the stomach and the duodenum. This study monitored intragastric and intraduodenal pressures of 7 healthy volunteers during the gastric emptying of an acid meal (pH 2) and an oleate meal (50 mM) in comparison with the gastric emptying of a 154 mM saline meal (pH 7) in order to elucidate the mechanisms of delayed gastric emptying seen with the acid and the fatty meals. Antroduodenal motility was measured by means of a continuously perfused catheter system, and fundic pressure was monitored by means of a water-filled balloon. Gastric emptying was measured with the double sampling dye dilution technique. As expected, the gastric emptying of the pH 7 meal (t 1/2 = 2.2 +/- 0.7 min) was significantly faster than that of the acid (t 1/2 = 11 +/- 2.1 min) and the oleate (t 1/2 = 18 +/- 2 min) meals. The rapid gastric emptying of the neutral meal was consistently associated with a significant increase in tonic fundic pressure (p less than 0.05), a feature never seen with the acid and the oleate meals. There was no change in duodenal motility with the gastric emptying of the neutral meal, whereas duodenal activity did tend to increase with the acid and oleate meals. Thus the proximal stomach appears to be the main determinant of variations in the gastric emptying of liquids, whereas the duodenum appears to have a less prominent role.
液体的胃排空由胃和十二指肠之间的压力梯度决定。本研究监测了7名健康志愿者在酸性餐（pH 2）和油酸盐餐（50 mM）胃排空过程中的胃内和十二指肠内压力，并与154 mM盐溶液餐（pH 7）的胃排空进行比较，以阐明酸性餐和脂肪餐导致胃排空延迟的机制。采用连续灌注导管系统测量十二指肠运动，用水囊监测胃底压力。用双样本染料稀释技术测量胃排空。正如预期的那样，pH 7餐的胃排空（t1/2 = 2.2 +/- 0.7分钟）明显快于酸性餐（t1/2 = 11 +/- 2.1分钟）和油酸盐餐（t1/2 = 18 +/- 2分钟）。中性餐的快速胃排空始终伴随着胃底张力压力的显著增加（p < 0.05），这是酸性餐和油酸盐餐从未出现过的特征。中性餐胃排空时十二指肠运动没有变化，而酸性餐和油酸盐餐时十二指肠活动确实有增加的趋势。因此，胃近端似乎是液体胃排空变化的主要决定因素，而十二指肠的作用似乎不那么突出。
