Borkakoti Jayanta, Ahmed Giasuddin, Hussain Syed Akhtar, Rai Arvind, Kar Premashis
PCR Hepatitis Laboratory, Department of Medicine, Maulana Azad Medical College and Associated Lok Nayak Jai Prakash Hospital, University of Delhi, New Delhi, India.
Arch Virol. 2014 Dec;159(12):3391-4. doi: 10.1007/s00705-014-2198-9. Epub 2014 Aug 7.
Hepatitis E virus (HEV) is evolving as a major global threat to public health, including in developed countries. We partially sequenced the ORF 2 capsid protein genes of HEV genomes from patients with acute liver failure, including pregnant women in the northern part of India. Five unique synonymous substitutions and one non-synonymous substitution, along with a novel mutation, P259S, in the capsid gene, were identified that might be associated with the poor outcome in the patients. Phylogenetic analysis revealed that the isolates belonged to genotype 1 with subtype 1a. The significance of these findings for disease pathogenicity needs to be investigated further.
戊型肝炎病毒（HEV）正逐渐成为对全球公共卫生的重大威胁，包括在发达国家。我们对来自急性肝衰竭患者（包括印度北部的孕妇）的HEV基因组的ORF 2衣壳蛋白基因进行了部分测序。在衣壳基因中鉴定出五个独特的同义替换和一个非同义替换，以及一个新突变P259S，这些可能与患者的不良预后相关。系统发育分析表明，分离株属于1型，亚型为1a。这些发现对疾病致病性的意义需要进一步研究。
