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本文引用的文献

1
Opposing functions of Akt isoforms in lung tumor initiation and progression.Akt亚型在肺癌发生和发展中的相反作用。
PLoS One. 2014 Apr 10;9(4):e94595. doi: 10.1371/journal.pone.0094595. eCollection 2014.
2
Activated AKT pathway promotes establishment of endometriosis.激活的 AKT 通路促进了子宫内膜异位症的建立。
Endocrinology. 2014 May;155(5):1921-30. doi: 10.1210/en.2013-1951. Epub 2014 Feb 26.
3
Genome-wide DNA methylation analysis predicts an epigenetic switch for GATA factor expression in endometriosis.全基因组DNA甲基化分析预测子宫内膜异位症中GATA因子表达的表观遗传转换。
PLoS Genet. 2014 Mar 6;10(3):e1004158. doi: 10.1371/journal.pgen.1004158. eCollection 2014 Mar.
4
Progesterone receptor in the vascular endothelium triggers physiological uterine permeability preimplantation.血管内皮中的孕激素受体触发胚胎植入前的生理性子宫通透性。
Cell. 2014 Jan 30;156(3):549-62. doi: 10.1016/j.cell.2013.12.025.
5
DNA methylation patterns of steroid receptor genes ESR1, ESR2 and PGR in deep endometriosis compromising the rectum.深部子宫内膜异位症累及直肠时甾体激素受体基因 ESR1、ESR2 和 PGR 的 DNA 甲基化模式。
Int J Mol Med. 2014 Apr;33(4):897-904. doi: 10.3892/ijmm.2014.1637. Epub 2014 Jan 28.
6
Temsirolimus with or without megestrol acetate and tamoxifen for endometrial cancer: a gynecologic oncology group study.替西罗莫司联合或不联合醋酸甲地孕酮和他莫昔芬治疗子宫内膜癌：一项妇科肿瘤学组研究。
Gynecol Oncol. 2014 Mar;132(3):585-92. doi: 10.1016/j.ygyno.2014.01.015. Epub 2014 Jan 20.
7
A genetic mouse model of invasive endometrial cancer driven by concurrent loss of Pten and Lkb1 Is highly responsive to mTOR inhibition.由同时缺失 Pten 和 Lkb1 驱动的侵袭性子宫内膜癌的基因小鼠模型对 mTOR 抑制高度敏感。
Cancer Res. 2014 Jan 1;74(1):15-23. doi: 10.1158/0008-5472.CAN-13-0544. Epub 2013 Dec 9.
8
Reduced connexin 43 in eutopic endometrium and cultured endometrial stromal cells from subjects with endometriosis.在位子宫内膜和子宫内膜异位症患者培养的子宫内膜基质细胞中连接蛋白 43 减少。
Mol Hum Reprod. 2014 Mar;20(3):260-70. doi: 10.1093/molehr/gat087. Epub 2013 Nov 22.
9
NME1 suppression of endometrial stromal cells promotes angiogenesis in the endometriotic milieu via stimulating the secretion of IL-8 and VEGF.NME1对子宫内膜间质细胞的抑制作用通过刺激IL-8和VEGF的分泌促进了子宫内膜异位症环境中的血管生成。
Int J Clin Exp Pathol. 2013 Sep 15;6(10):2030-8. eCollection 2013.
10
IL-22 in the endometriotic milieu promotes the proliferation of endometrial stromal cells via stimulating the secretion of CCL2 and IL-8.子宫内膜异位症环境中的白细胞介素-22通过刺激趋化因子配体2（CCL2）和白细胞介素-8（IL-8）的分泌促进子宫内膜间质细胞的增殖。
Int J Clin Exp Pathol. 2013 Sep 15;6(10):2011-20. eCollection 2013.

AKT对子宫内膜疾病中孕酮作用的影响。

Influence of AKT on progesterone action in endometrial diseases.

作者信息

Lee Irene I, Kim J Julie

机构信息

Division of Reproductive Science in Medicine, Department of Obstetrics and Gynecology, Robert H. Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, Illinois.

Division of Reproductive Science in Medicine, Department of Obstetrics and Gynecology, Robert H. Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, Illinois

出版信息

Biol Reprod. 2014 Sep;91(3):63. doi: 10.1095/biolreprod.114.119255. Epub 2014 Aug 6.

DOI:10.1095/biolreprod.114.119255
PMID:25100707
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4435059/
Abstract

Progesterone plays an essential role in the maintenance of the endometrium; it prepares the endometrium for pregnancy, promotes decidualization, and inhibits estrogen-dependent proliferation. Progesterone function is often dysregulated in endometrial disease states. In addition, the PI3K/AKT signaling pathway is often overactive in endometrial pathologies and promotes the survival and proliferation of the diseased cells. Understanding how AKT influences progesterone action is critical in improving hormone-based therapies in endometrial pathologies. Here, we summarize recent studies investigating the crosstalk between the AKT pathway and progesterone receptor function in endometriosis and endometrial cancer.

摘要

孕酮在维持子宫内膜方面起着至关重要的作用；它使子宫内膜为妊娠做好准备，促进蜕膜化，并抑制雌激素依赖性增殖。在子宫内膜疾病状态下，孕酮功能常常失调。此外，PI3K/AKT信号通路在子宫内膜病变中常常过度活跃，并促进病变细胞的存活和增殖。了解AKT如何影响孕酮作用对于改善子宫内膜病变的激素疗法至关重要。在此，我们总结了最近关于子宫内膜异位症和子宫内膜癌中AKT通路与孕酮受体功能之间相互作用的研究。