Shikino Kiyoshi, Ikusaka Masatomi, Yamashita Tomoko
Department of General Medicine, Chiba University Hospital, Chiba, Japan.
BMJ Case Rep. 2014 Jul 4;2014:bcr2014204558. doi: 10.1136/bcr-2014-204558.
A 34-year-old Japanese woman presented with a 2-year history of generalised bone pain, muscle weakness and gait disturbance. The patient had been following a restricted diet (without fish or dairy products) and avoiding ultraviolet exposure for 8 years to manage her worsening atopic dermatitis. Physical examination revealed generalised bone tenderness and bilateral symmetric proximal muscle weakness. Vitamin D-deficient osteomalacia was diagnosed based on the laboratory examination findings, which indicated high serum alkaline phosphatase, high intact parathyroid hormone, and low 25-hydroxyvitamin D levels. Her symptoms improved after oral active vitamin D and calcium administration. To the best our knowledge, this case is the first report of vitamin D-deficient osteomalacia in an adult patient due to excessive dietary restriction for managing atopic dermatitis. We emphasise the importance of increasing awareness of vitamin D deficiency as a risk factor for the development of osteomalacia, and caution against excessive avoidance of sun exposure and dietary restriction.
一名34岁的日本女性出现全身骨痛、肌肉无力和步态障碍2年。该患者为控制日益加重的特应性皮炎,已遵循限制饮食(不吃鱼或奶制品)并避免紫外线照射8年。体格检查发现全身骨骼压痛和双侧对称性近端肌肉无力。根据实验室检查结果诊断为维生素D缺乏性骨软化症,结果显示血清碱性磷酸酶升高、甲状旁腺激素原升高和25-羟维生素D水平降低。口服活性维生素D和钙剂后,她的症状有所改善。据我们所知,该病例是因过度饮食限制治疗特应性皮炎导致成人维生素D缺乏性骨软化症的首例报告。我们强调提高对维生素D缺乏作为骨软化症发生风险因素的认识的重要性,并告诫不要过度避免阳光照射和饮食限制。