Bel Abed Hassen, Mammoliti Oscar, Bande Omprakash, Van Lommen Guy, Herdewijn Piet
Rega Institute for Medical Research, Katholieke Universiteit Leuven, Minderbroedersstraat 10, B-3000 Leuven, Belgium.
Org Biomol Chem. 2014 Sep 28;12(36):7159-66. doi: 10.1039/c4ob01201a.
The elaboration of the first organophosphorus-catalyzed diaza-Wittig reaction is reported. This catalytic reaction is applied to the synthesis of substituted pyridazine and phthalazine derivatives bearing electron-withdrawing groups with good to excellent yields from substrates containing a diazo functionality as the starting material and a phospholene oxide as the catalyst.
报道了首例有机磷催化的重氮-维蒂希反应的详细过程。该催化反应应用于合成带有吸电子基团的取代哒嗪和酞嗪衍生物，以含有重氮官能团的底物为起始原料，氧化膦烯为催化剂，产率良好至优异。
