Büttner U
Department of Neurology, Ludwig-Maximilians-University, Munich, FRG.
Rev Neurol (Paris). 1989;145(8-9):560-6.
Experimental evidence demonstrates that the primate cerebellum plays an essential role in the generation of smooth pursuit eye movements (SPEM). The same neural elements also take part in the generation of the 'direct' component of OKN, which is responsible for an initial jump in slow phase eye velocity during constant velocity stimulation and the optokinetic response above 0,05 Hz. In addition to the extensively studied floccular region, recent experiments also indicate a role of the mid-vermis (lobule VI and VII) in SPEM control. The 'indirect' or 'velocity storage' component of OKN produces more gradual changes in slow phase eye velocity, and basically depends only on brainstem mechanisms. It is, however, under the inhibitory control of the nodulus and ventral uvula. The loss of this control after lesions could explain disorders like periodic alternating nystagmus.
实验证据表明，灵长类动物的小脑在平稳跟踪眼球运动（SPEM）的产生中起着至关重要的作用。相同的神经元件也参与视动性眼震（OKN）“直接”成分的产生，该成分负责在匀速刺激期间慢相眼速度的初始跃升以及高于0.05Hz的视动反应。除了广泛研究的绒球区域外，最近的实验还表明小脑蚓部中部（小叶VI和VII）在SPEM控制中发挥作用。OKN的“间接”或“速度存储”成分在慢相眼速度上产生更渐进的变化，并且基本上仅依赖于脑干机制。然而，它受小结和腹侧蚓垂的抑制性控制。损伤后这种控制的丧失可以解释诸如周期性交替性眼球震颤等病症。
