Hall Wendy L, Brito Marcela Fiuza, Huang Junlan, Wood Lucy V, Filippou Androulla, Sanders Thomas A B, Berry Sarah E E
Diabetes & Nutritional Sciences Division, School of Medicine, King's College London, Franklin-Wilkins Building, 150 Stamford Street, London, SE1 9NH, UK,
Lipids. 2014 Sep;49(9):895-904. doi: 10.1007/s11745-014-3936-1. Epub 2014 Aug 8.
Palm oil that has been interesterified to produce a higher proportion of palmitic acid (16:0) in the sn-2 position reduces postprandial lipemia in young, normolipidemic men and women, but effects in older subjects with higher fasting triacylglycerol (TAG) concentrations are unknown. We tested the hypothesis that high-fat meals rich in interesterified palm olein (IPO) decrease lipemia and alter plasma lipoprotein fraction composition compared to native palm olein (NPO) in men aged 40-70 years with fasting TAG concentrations ≥1.2 mmol/L. Postprandial changes in plasma lipids following meals containing 75 g fat (NPO and IPO) were compared using a randomized, double-blind crossover design (n = 11). Although there were no significant differences in plasma TAG concentrations between meals over the total 6-h postprandial measurement period, IPO resulted in a decreased plasma TAG response during the first 4 h of the postprandial period (iAUC 1.65 mmol/L h, 95% CI 1.01-2.29) compared to NPO (iAUC 2.33 mmol/L h, 95% CI 1.58-3.07); meal effect P = 0.024. Chylomicron fraction TAG concentrations at 4-6 h were slightly reduced following IPO compared to NPO [NPO-IPO mean difference 0.29 mmol/L (95% CI -0.01-0.59), P = 0.055]. There were no differences in IDL fraction TAG, cholesterol or apolipoprotein B48 concentrations following IPO compared with NPO. In conclusion, consuming a meal containing palm olein with a higher proportion of 16:0 in the sn-2 position decreases postprandial lipemia compared to native palm olein during the early phase of the postprandial period in men with higher than optimal fasting triacylglycerol concentrations.
经过酯交换处理以在sn-2位产生更高比例棕榈酸（16:0）的棕榈油，可降低年轻、血脂正常的男性和女性的餐后血脂，但对空腹三酰甘油（TAG）浓度较高的老年受试者的影响尚不清楚。我们检验了这样一个假设：与天然棕榈油精（NPO）相比，富含酯交换棕榈油精（IPO）的高脂肪餐食会降低40至70岁、空腹TAG浓度≥1.2 mmol/L男性的血脂，并改变血浆脂蛋白组分的组成。采用随机、双盲交叉设计（n = 11）比较了含75 g脂肪餐食（NPO和IPO）后血浆脂质的餐后变化。尽管在餐后6小时的总测量期内，餐食之间的血浆TAG浓度没有显著差异，但与NPO相比，IPO在餐后最初4小时导致血浆TAG反应降低（iAUC 1.65 mmol/L·h，95%CI 1.01 - 2.29），而NPO为（iAUC 2.33 mmol/L·h，95%CI 1.58 - 3.07）；餐食效应P = 0.024。与NPO相比，IPO后4至6小时乳糜微粒组分TAG浓度略有降低[NPO - IPO平均差异0.29 mmol/L（95%CI -0.01 - 0.59），P = 0.055]。与NPO相比，IPO后中间密度脂蛋白组分TAG、胆固醇或载脂蛋白B48浓度没有差异。总之，对于空腹三酰甘油浓度高于最佳水平的男性，在餐后早期，食用sn-2位16:0比例较高的棕榈油精餐食与天然棕榈油精相比，可降低餐后血脂。
