Department of Medical Nutrition, Graduate School of East-West Medical Science, Kyung Hee University, Gyeonggi 446-701, Korea. ; Nutrition Team, Kyung Hee University Hospital at Gangdong, Seoul 134-727, Korea.
Department of Food and Nutrition, Changwon National University, Changwon 641-773, Korea.
Nutr Res Pract. 2014 Aug;8(4):469-75. doi: 10.4162/nrp.2014.8.4.469. Epub 2014 Jul 17.
BACKGROUND/OBJECTIVE: The goal of the present study was to investigate the effects of moderate caloric restriction on β-cell function and insulin sensitivity in middle-aged obese Korean women.
SUBJECTS/METHODS: Fifty-seven obese pre-menopausal Korean women participated in a 12-week calorie restriction program. Data on total cholesterol (TC), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), triglycerides (TG), and fasting serum levels of glucose, insulin, C-peptide, blood pressure, leptin and anthropometrics were collected. A dietary intake assessment was based on three days of food recording. Additionally, β-cell function [homeostasis model assessment of β-cell (HOMA-β), insulinogenic index (ISI), C-peptide:glucose ratio, and area under curve insulin/glucose (AUCins/glu)] and insulin sensitivity [homeostasis model assessment for insulin resistance (HOMA-IR), Quantitative insulin-sensitivity check index (QUICKI) and Matsuda index (MI)] were recorded.
When calories were reduced by an average of 422 kcal/day for 12 weeks, BMI (-2.7%), body fat mass (-10.2%), and waist circumference (-5%) all decreased significantly (P < 0.05). After calorie restriction, weight, body fat percentage, hip circumference, BP, TC, HDL-C, LDL-C, plasma glucose at fasting, insulin at fasting and 120 min, AUCglu and the insulin area under the curve all decreased significantly (all P < 0.05), while insulin sensitivity (HOMA-IR, QUICKI and Matsuda index) measured by OGTT improved significantly (P < 0.01).
Moderate weight loss due to caloric restriction with reduction in insulin resistance improves glucose tolerance and insulin sensitivity in middle-aged obese women and thereby may help prevent the development of type 2 diabetes mellitus.
背景/目的：本研究旨在探讨适度热量限制对中年肥胖韩国女性胰岛β细胞功能和胰岛素敏感性的影响。
受试者/方法：57 名肥胖绝经前韩国女性参与了为期 12 周的热量限制计划。收集总胆固醇（TC）、高密度脂蛋白胆固醇（HDL-C）、低密度脂蛋白胆固醇（LDL-C）、甘油三酯（TG）以及空腹血糖、胰岛素、C 肽、血压、瘦素和人体测量学数据。通过三天的食物记录进行膳食摄入量评估。此外，还记录了胰岛β细胞功能[稳态模型评估的胰岛β细胞（HOMA-β）、胰岛素生成指数（ISI）、C 肽：葡萄糖比值和胰岛素/葡萄糖曲线下面积（AUCins/glu）]和胰岛素敏感性[稳态模型评估的胰岛素抵抗（HOMA-IR）、定量胰岛素敏感性检查指数（QUICKI）和 Matsuda 指数（MI）]。
在 12 周内平均减少 422 卡路里热量时，BMI（-2.7%）、体脂肪量（-10.2%）和腰围（-5%）均显著下降（P < 0.05）。热量限制后，体重、体脂肪百分比、臀围、血压、TC、HDL-C、LDL-C、空腹血糖、空腹和 120 分钟胰岛素、AUCglu 和胰岛素曲线下面积均显著下降（均 P < 0.05），而 OGTT 测定的胰岛素敏感性（HOMA-IR、QUICKI 和 Matsuda 指数）显著改善（P < 0.01）。
由于热量限制导致体重适度减轻，同时改善了胰岛素抵抗，从而改善了中年肥胖女性的葡萄糖耐量和胰岛素敏感性，有助于预防 2 型糖尿病的发生。
