Woodard C, Huang T, Sun H, Helfand S L, Carlson J
Department of Biology, Yale University, New Haven, Connecticut 06511.
Genetics. 1989 Oct;123(2):315-26. doi: 10.1093/genetics/123.2.315.
A simple means of measuring Drosophila olfactory response is described, and the behavior which it measures is characterized. The assay was used to screen for X-linked mutants defective in olfactory function. Six ota mutants were isolated and characterized (ota = olfactory trap abnormal). Four of the mutants were found to be abnormal in another chemosensory behavior as well. Two of the mutant phenotypes extend to include another sensory system: they are defective in visual system physiology. All were normal, however, in a test of giant fiber system physiology. Two of the mutations are dominant, and the recessive mutations define two complementation groups. Mutations representing each complementation group, as well as one of the dominant mutations, were mapped. For the mutants with defective visual system physiology, the visual defects were shown to cosegregate with olfactory phenotypes.
描述了一种测量果蝇嗅觉反应的简单方法，并对其测量的行为进行了特征描述。该测定法用于筛选嗅觉功能有缺陷的X连锁突变体。分离并鉴定了六个ota突变体（ota = 嗅觉陷阱异常）。发现其中四个突变体在另一种化学感受行为中也表现异常。两个突变体表型扩展到包括另一个感觉系统：它们在视觉系统生理学方面存在缺陷。然而，在巨纤维系统生理学测试中，所有突变体均正常。其中两个突变是显性的，隐性突变定义了两个互补群。对代表每个互补群的突变以及其中一个显性突变进行了定位。对于视觉系统生理学有缺陷的突变体，视觉缺陷与嗅觉表型共分离。
