Singapore Bioimaging Consortium, Agency for Science, Technology and Research, 138667, Singapore.
Small. 2014 Dec 29;10(24):5030-4. doi: 10.1002/smll.201401713. Epub 2014 Aug 11.
A metal carbonyl-functionalized nanostructured substrate can be used in a rapid and simple assay for the detection of A1AT, a potential biomarker for bladder cancer, in clinical urine samples. The assay involves monitoring changes in the carbonyl stretching vibrations of the metal carbonyl via surface-enhanced Raman spectroscopy (SERS). These vibrations lie in the absorption spectral window of 1800-2200 cm(-1), which is free of any spectral interference from biomolecules.
一种金属羰基功能化的纳米结构基底可用于快速、简单地检测临床尿液样本中的 A1AT（膀胱癌的潜在生物标志物）。该检测方法涉及通过表面增强拉曼光谱（SERS）监测金属羰基的羰基伸缩振动的变化。这些振动位于 1800-2200 cm(-1) 的吸收光谱窗口，该窗口不受任何生物分子的光谱干扰。
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