小眼畸形相关转录因子及色素沉着在黑色素瘤中的作用
The roles of microphthalmia-associated transcription factor and pigmentation in melanoma.
作者信息
Hsiao Jennifer J, Fisher David E
机构信息
Biological and Biomedical Sciences, Harvard Medical School, Boston, MA 02115, USA; Cutaneous Biology Research Center, Department of Dermatology, Massachusetts General Hospital, Harvard Medical School, Building 149, 13th Street, Charlestown, MA 02129, USA.
Biological and Biomedical Sciences, Harvard Medical School, Boston, MA 02115, USA; Cutaneous Biology Research Center, Department of Dermatology, Massachusetts General Hospital, Harvard Medical School, Building 149, 13th Street, Charlestown, MA 02129, USA.
出版信息
Arch Biochem Biophys. 2014 Dec 1;563:28-34. doi: 10.1016/j.abb.2014.07.019. Epub 2014 Aug 9.
MITF and pigmentation play important roles in both normal melanocyte and transformed melanoma cell biology. MITF is regulated by many pathways and it also regulates many targets, some of which are still being discovered and functionally validated. MITF is involved in a wide range of processes in melanocytes, including pigment synthesis and lineage survival. Pigmentation itself plays an important role as the interface between genetic and environmental factors that contribute to melanoma.
小眼畸形相关转录因子（MITF）和色素沉着在正常黑素细胞及转化的黑色素瘤细胞生物学中均发挥重要作用。MITF受多种信号通路调控，同时它也调控许多靶点，其中一些靶点仍有待发现并进行功能验证。MITF参与黑素细胞的多种过程，包括色素合成和谱系存活。色素沉着本身作为导致黑色素瘤的遗传和环境因素之间的界面发挥着重要作用。
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