β-2肾上腺素能受体（ADRB2）基因多态性与哮喘风险：病例对照研究的荟萃分析
Beta-2 adrenergic receptor (ADRB2) gene polymorphisms and the risk of asthma: a meta-analysis of case-control studies.
作者信息
Liang Si-Qiao, Chen Xiao-Li, Deng Jing-Min, Wei Xuan, Gong Chen, Chen Zhang-Rong, Wang Zhi-Bo
机构信息
Department of Respiratory Medicine, First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China.
出版信息
PLoS One. 2014 Aug 11;9(8):e104488. doi: 10.1371/journal.pone.0104488. eCollection 2014.
BACKGROUND AND OBJECTIVE
A number of studies have assessed the relationship between beta-2 adrenergic receptor (ADRB2) gene polymorphisms and asthma risk. However, the results are inconsistent. A meta-analysis that focused on the association between asthma and all ADRB2 polymorphisms with at least three case-control studies was thus performed.
METHODS
A literature search of the PubMed, Embase, Web of Science, CNKI, and Wangfang databases was conducted. Odds ratios with 95% confidence intervals were used to assess the strength of associations.
RESULTS
Arg16Gly, Gln27Glu, Thr164Ile, and Arg19Cys single nucleotide polymorphisms (SNPs) were identified in 46 case-control studies. The results showed that not all of the SNPs were associated with asthma in the overall population. Significant associations were found for the Arg16Gly polymorphism in the South American population via dominant model comparison (OR = 1.754, 95% CI = 1.179-2.609, I2 = 16.9%, studies = 2, case = 314, control = 237) in an analysis stratified by ethnicity. For the Gln27Glu polymorphism, a protective association was found in children via recessive model comparison (OR = 0.566, 95% CI = 0.417-0.769, I2 = 0.0%, studies = 11, case = 1693, control = 502) and homozygote genotype comparison (OR = 0.610, 95% CI = 0.434-0.856, I2 = 0.0%, studies = 11, case = 1693, control = 1502), and in adults via dominant model comparison (OR = 0.864, 95% CI = 0.768-0.971, I2 = 46.9%, n = 18, case = 3160, control = 3433).
CONCLUSIONS
None of the ADRB2 gene polymorphisms were reproducibly associated with a risk of asthma across ethnic groups in the general population.
背景与目的
多项研究评估了β-2肾上腺素能受体（ADRB2）基因多态性与哮喘风险之间的关系。然而，结果并不一致。因此，进行了一项荟萃分析，重点关注哮喘与所有至少有三项病例对照研究的ADRB2多态性之间的关联。
方法
对PubMed、Embase、Web of Science、CNKI和万方数据库进行文献检索。采用95%置信区间的比值比来评估关联强度。
结果
在46项病例对照研究中鉴定出了Arg16Gly、Gln27Glu、Thr164Ile和Arg19Cys单核苷酸多态性（SNP）。结果表明，并非所有SNP在总体人群中都与哮喘相关。在按种族分层的分析中，通过显性模型比较发现南美人群中Arg16Gly多态性存在显著关联（OR = 1.754，95% CI = 1.179 - 2.609，I2 = 16.9%，研究 = 2，病例 = 314，对照 = 237）。对于Gln27Glu多态性，在儿童中通过隐性模型比较（OR = 0.566，95% CI = 0.417 - 0.769，I2 = 0.0%，研究 = 11，病例 = 1693，对照 = 502）和纯合子基因型比较（OR = 0.610，95% CI = 0.434 - 0.856，I2 = 0.0%，研究 = 11，病例 = 1693，对照 = 1502）发现有保护关联，在成人中通过显性模型比较（OR = 0.864，95% CI = 0.768 - 0.971，I2 = 46.9%，n = 18，病例 = 3160，对照 = 3433）发现有保护关联。
结论
在普通人群中，ADRB2基因多态性均未在不同种族间与哮喘风险产生可重复的关联。
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