苏丹支气管哮喘患者的基因多态性：一项病例对照研究。
gene polymorphisms among Sudanese patients with bronchial asthma: a case-control study.
作者信息
Abdalla Menas A, Hamdan Hamdan Z
机构信息
Department of Pharmacology, Faculty of Pharmacy, Al-Neelain University, Khartoum, Sudan.
Department of Pathology, College of Medicine, Qassim University, Saudi Arabia.
出版信息
Mol Biol Res Commun. 2025;14(1):27-30. doi: 10.22099/mbrc.2024.50865.2017.
Genetic polymorphisms in interleukin-13 () gene have been associated with asthma susceptibility in different ethnicities. We investigated the association of two polymorphisms in the gene [rs1800925 (c.-93+487C>T), and rs20541 (p.Gln144Arg)] with asthma susceptibility among Sudanese patients. A case-control study was conducted at Al-Shaab Teaching Hospital between April and October 2022. Involving fifty asthmatic patients and fifty controls. The genotypes were determined using an allele-specific polymerase chain reaction. For rs1800925, a significant association with asthma in multivariate analysis (aOR=3.15, 95% CI: 1.13-8.76; p=0.028). The T allele was the most frequent in cases and showed a significant association with asthma (aOR=1.99, 95% CI: 1.13-3.5; p=0.016). The rs20541 did not show any association with asthma. The rs1800925 is associated with an increased risk of asthma in Sudanese patients.
白细胞介素 - 13（IL - 13）基因的遗传多态性已被证明与不同种族的哮喘易感性相关。我们调查了该基因中的两个多态性位点[rs1800925（c.-93 + 487C>T）和rs20541（p.Gln144Arg）]与苏丹患者哮喘易感性之间的关联。2022年4月至10月在沙巴布教学医院进行了一项病例对照研究。纳入了50名哮喘患者和50名对照。使用等位基因特异性聚合酶链反应确定基因型。对于rs1800925，在多变量分析中与哮喘存在显著关联（调整后比值比[aOR]=3.15，95%置信区间[CI]：1.13 - 8.76；p = 0.028）。T等位基因在病例中最为常见，并且与哮喘存在显著关联（aOR = 1.99，95% CI：1.13 - 3.5；p = 0.016）。rs20541与哮喘未显示出任何关联。rs1800925与苏丹患者哮喘风险增加相关。
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