Department of Immunology, School of Basic Medical Sciences, Capital Medical University, You An Men, Beijing, P. R. China.
Department of Chest Surgery, Beijing Anzhen Hospital, Capital Medical University, Beijing, P. R. China.
J Biol Regul Homeost Agents. 2018 Sep-Oct;32(5):1105-1116.
Lung cancer is the leading cause of cancer-related morbidity and mortality worldwide. Interaction of nascent or established lung tumour cells with various cytokines and infiltrating immune cells has been implicated in lung cancer pathogenesis. In this study, we systematically analysed immunoreactivity for IL-17A, IL-17E and IL-17F and their relevant receptors in the lung sections from non-small cell lung cancer (NSCLC) and normal control. Immunoreactivity for IL-17A, IL-17F, IL-17RA and IL- 17RC, but not IL-17RB was significantly elevated in NSCLC compared with controls, while IL-17E was reduced. The median numbers of infiltrating lymphocytes and neutrophils and global macrophage (CD68) immunoreactivity of phagocytes were also elevated in NSCLC compared with control tissue sections. Furthermore, correlation between the expression of IL-17A and its receptors IL-17RA and IL- 17RC varied according to NSCLC histopathological type. These data suggest that IL-17A, E, F and their receptors IL-17RA, RB, RC may be involved in the pathogenesis of NSCLC. Further understanding of the relationship between the IL-17/IL-17R axis and the tumour inflammatory microenvironment may reveal new therapeutic targets.
肺癌是全球癌症相关发病率和死亡率的主要原因。新出现或已建立的肺癌细胞与各种细胞因子和浸润免疫细胞的相互作用被认为与肺癌的发病机制有关。在这项研究中，我们系统地分析了非小细胞肺癌（NSCLC）和正常对照肺组织切片中 IL-17A、IL-17E 和 IL-17F 及其相关受体的免疫反应性。与对照组相比，NSCLC 中 IL-17A、IL-17F、IL-17RA 和 IL-17RC 的免疫反应性显著升高，而 IL-17E 则降低。与对照组织切片相比，浸润淋巴细胞和中性粒细胞的中位数数量以及巨噬细胞（CD68）的总吞噬细胞免疫反应性也升高。此外，IL-17A 及其受体 IL-17RA 和 IL-17RC 的表达之间的相关性因 NSCLC 的组织病理学类型而异。这些数据表明，IL-17A、E、F 及其受体 IL-17RA、RB、RC 可能参与 NSCLC 的发病机制。进一步了解 IL-17/IL-17R 轴与肿瘤炎症微环境之间的关系可能揭示新的治疗靶点。
