Guerreiro Rita, Hardy John
Department of Molecular Neuroscience, Institute of Neurology, UCL, 1 Wakefield Street, London, WC1N 1PJ, UK,
Neurotherapeutics. 2014 Oct;11(4):732-7. doi: 10.1007/s13311-014-0295-9.
The analyses of genetic factors contributing to Alzheimer's disease (AD) and other dementias have evolved at the same pace as genetic and genomic technologies are developed and improved. The identification of the first genes involved in AD arose from family-based studies, but risk factors have mainly been identified by studies comparing groups of patients with groups of controls. The best outcomes have been heavily associated with the capacity of interrogating genetic variability at the genome level without any particular a priori hypothesis. In this review we assess the role of genetic family studies in Alzheimer's disease and other dementias within the current status of dementias' and, particularly, AD's genetic architecture.
对导致阿尔茨海默病(AD)和其他痴呆症的遗传因素的分析,与遗传和基因组技术的发展与改进同步进行。与AD相关的首批基因是通过基于家系的研究确定的,但风险因素主要是通过比较患者组和对照组的研究来确定的。最佳研究成果与在没有任何特定先验假设的情况下在基因组水平上探究遗传变异性的能力密切相关。在本综述中,我们在痴呆症,特别是AD的遗传结构现状下,评估遗传家系研究在阿尔茨海默病和其他痴呆症中的作用。