桥粒芯蛋白-2促进表皮生长因子受体的激活。
Plakophilin-2 promotes activation of epidermal growth factor receptor.
作者信息
Kazlauskas Andrius
机构信息
Schepens Eye Research Institute, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts, USA
出版信息
Mol Cell Biol. 2014 Oct;34(20):3778-9. doi: 10.1128/MCB.00968-14. Epub 2014 Aug 11.
Abstract
While growth factor-driven dimerization of receptor tyrosine kinases (RTKs) is a simple and intuitive mechanism of activating RTKs, K.-I. Arimoto et al. (Mol. Cell. Biol. 34:3843-3854, 2014, doi:10.1128/MCB.00758-14) describe a novel means of promoting the activity of RTKs. Namely, plakophilin-2 (PKP2) associates with the epidermal growth factor receptor (EGFR) and enhances its ligand-dependent and ligand-independent activity. This discovery suggests that antagonizing PKP2 may be a new therapeutic opportunity to combat tumors in which activation of EGFR contributes to pathogenesis.
摘要
虽然生长因子驱动的受体酪氨酸激酶（RTK）二聚化是激活RTK的一种简单直观的机制，但有本光一等人（《分子与细胞生物学》34:3843 - 3854，2014年，doi:10.1128/MCB.00758 - 14）描述了一种促进RTK活性的新方法。具体而言，桥粒芯蛋白2（PKP2）与表皮生长因子受体（EGFR）结合，并增强其依赖配体和不依赖配体的活性。这一发现表明，拮抗PKP2可能是对抗EGFR激活促成发病机制的肿瘤的一个新的治疗机会。
相似文献
1
Plakophilin-2 promotes activation of epidermal growth factor receptor.
Mol Cell Biol. 2014 Oct;34(20):3778-9. doi: 10.1128/MCB.00968-14. Epub 2014 Aug 11.
2
Plakophilin-2 promotes tumor development by enhancing ligand-dependent and -independent epidermal growth factor receptor dimerization and activation.
Mol Cell Biol. 2014 Oct;34(20):3843-54. doi: 10.1128/MCB.00758-14. Epub 2014 Aug 11.
3
Plakophilin-2 accelerates cell proliferation and migration through activating EGFR signaling in lung adenocarcinoma.
Pathol Res Pract. 2019 Jul;215(7):152438. doi: 10.1016/j.prp.2019.152438. Epub 2019 May 13.
4
Epidermal growth factor receptor levels increase but epidermal growth factor receptor ligand levels decrease in mouse mammary tumors during progression from hormone dependence to hormone independence.
Breast Cancer Res Treat. 1993;26(3):289-95. doi: 10.1007/BF00665807.
5
Loss of BRCA1 leads to an increase in epidermal growth factor receptor expression in mammary epithelial cells, and epidermal growth factor receptor inhibition prevents estrogen receptor-negative cancers in BRCA1-mutant mice.
Breast Cancer Res. 2011 Mar 11;13(2):R30. doi: 10.1186/bcr2850.
6
A new model system identifies epidermal growth factor receptor-human epidermal growth factor receptor 2 (HER2) and HER2-human epidermal growth factor receptor 3 heterodimers as potent inducers of oesophageal epithelial cell invasion.
J Pathol. 2017 Dec;243(4):481-495. doi: 10.1002/path.4987. Epub 2017 Nov 5.
7
Microbead arrays for the analysis of ErbB receptor tyrosine kinase activation and dimerization in breast cancer cells.
Assay Drug Dev Technol. 2010 Feb;8(1):27-36. doi: 10.1089/adt.2009.0208.
8
Ligand-induced activation of epidermal growth factor receptor in intact rat mammary adenocarcinoma cells without detectable receptor phosphorylation.
J Biol Chem. 1992 Jun 15;267(17):11872-80.
9
Exogenous ganglioside GD1a enhances epidermal growth factor receptor binding and dimerization.
J Biol Chem. 2004 Aug 27;279(35):36481-9. doi: 10.1074/jbc.M402880200. Epub 2004 Jun 23.
10
p90 Ribosomal S6 kinase 2, a novel GPCR kinase, is required for growth factor-mediated attenuation of GPCR signaling.
Biochemistry. 2010 Mar 30;49(12):2657-71. doi: 10.1021/bi901921k.
引用本文的文献
1
Plakophilin-2 Promotes Lung Adenocarcinoma Development via Enhancing Focal Adhesion and Epithelial-Mesenchymal Transition.
Cancer Manag Res. 2021 Jan 22;13:559-570. doi: 10.2147/CMAR.S281663. eCollection 2021.
2
LINC00680 and TTN-AS1 Stabilized by EIF4A3 Promoted Malignant Biological Behaviors of Glioblastoma Cells.
Mol Ther Nucleic Acids. 2020 Mar 6;19:905-921. doi: 10.1016/j.omtn.2019.10.043. Epub 2019 Nov 16.
3
Increased expression of plakophilin 3 is associated with poor prognosis in ovarian cancer.
Medicine (Baltimore). 2019 Mar;98(10):e14608. doi: 10.1097/MD.0000000000014608.
4
Analysis of porcine body size variation using re-sequencing data of miniature and large pigs.
BMC Genomics. 2018 Sep 19;19(1):687. doi: 10.1186/s12864-018-5009-y.
5
Plakophilin-2 induced EGFR phosphorylation: a focus on the intracellular activators of EGFR.
Receptors Clin Investig. 2014;2(1):e485. doi: 10.14800/rci.485.
本文引用的文献
1
Plakophilin-2 promotes tumor development by enhancing ligand-dependent and -independent epidermal growth factor receptor dimerization and activation.
Mol Cell Biol. 2014 Oct;34(20):3843-54. doi: 10.1128/MCB.00758-14. Epub 2014 Aug 11.
2
Architecture and membrane interactions of the EGF receptor.
Cell. 2013 Jan 31;152(3):557-69. doi: 10.1016/j.cell.2012.12.030.
3
Conformational coupling across the plasma membrane in activation of the EGF receptor.
Cell. 2013 Jan 31;152(3):543-56. doi: 10.1016/j.cell.2012.12.032.
4
The juxtamembrane region of the EGF receptor functions as an activation domain.
Mol Cell. 2009 Jun 26;34(6):641-51. doi: 10.1016/j.molcel.2009.04.034.
5
Growth factors outside of the platelet-derived growth factor (PDGF) family employ reactive oxygen species/Src family kinases to activate PDGF receptor alpha and thereby promote proliferation and survival of cells.
J Biol Chem. 2009 Mar 6;284(10):6329-36. doi: 10.1074/jbc.M808426200. Epub 2009 Jan 6.
6
MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signaling.
Science. 2007 May 18;316(5827):1039-43. doi: 10.1126/science.1141478. Epub 2007 Apr 26.
7
Stimulatory autoantibodies to the PDGF receptor in systemic sclerosis.
N Engl J Med. 2006 Jun 22;354(25):2667-76. doi: 10.1056/NEJMoa052955.
8
Potentiation of epidermal growth factor receptor-mediated oncogenesis by c-Src: implications for the etiology of multiple human cancers.
Proc Natl Acad Sci U S A. 1995 Jul 18;92(15):6981-5. doi: 10.1073/pnas.92.15.6981.
9
Self-phosphorylation of epidermal growth factor receptor: evidence for a model of intermolecular allosteric activation.
Biochemistry. 1987 Mar 10;26(5):1434-42. doi: 10.1021/bi00379a034.
10
Activation of the platelet-derived growth factor receptor by the bovine papillomavirus E5 transforming protein.
EMBO J. 1991 Apr;10(4):845-55. doi: 10.1002/j.1460-2075.1991.tb08017.x.
Zotero 插件