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STOPP-START药物审查:印度尼西亚一家三级医院的非随机试验,旨在提高用药合理性并缩短老年人住院时间。

STOPP-START Medication Review: A Non-Randomized Trial in an Indonesian Tertiary Hospital to Improve Medication Appropriateness and to Reduce the Length of Stay of Older Adults.

作者信息

Herawati Fauna, Maharjana Ida Bagus Nyoman, Kuswardhani Tuty, Susilo Astrid Pratidina

机构信息

University of Surabaya, Surabaya, Indonesia.

Udayana University, Kabupaten Badung, Bali, Indonesia.

出版信息

Hosp Pharm. 2021 Dec;56(6):668-677. doi: 10.1177/0018578720942227. Epub 2020 Jul 13.

Abstract

Inappropriate prescribing may lead to medication errors among older adults. Pharmacists can curb the occurrences of these errors by conducting medication reviews. Screening Tool of Older Person's Prescriptions (STOPP) or Screening Tool to Alert doctors to Right Treatments (START) may curb the incidence of adverse drug reactions and improve medication appropriateness by providing guides about when particular types of medications should be started or stopped. This study aimed to evaluate the use of STOPP/START to improve the Adapted Medication Appropriateness Index (MAI), to reduce the risk of ADRs (GerontoNet score), and length of stay (LOS). Geriatric Inpatient Ward, Sanglah General Hospital, Bali, Indonesia. A non-randomized controlled trial was conducted in older adults (>60 years) who were selected consecutively from inpatient units in a tertiary hospital in Bali, Indonesia. The intervention group received medication reviews by pharmacists in collaboration with physicians to assess its appropriateness with STOPP/START criteria on admission and during their stay at the hospital. The control group obtained standard care. The outcomes were measured using the Adapted MAI, GerontoNet Score, and LOS. Thirty patients in the intervention group and 33 patients in the control group were included in this study. The adapted MAI was 2.97 (2.25) and 9.94 (6.14) with  < .001. The GerontoNet score was 3.33 (2.28) and 5.18 (2.10) with  = .003, LOS was 7.63 (3.00) days and 14.18 (9.97) days with  = .011, respectively. The use of STOPP/START as a tool for medication review improved medication appropriateness and reduced ADR risk and LOS.

摘要

不恰当的处方开具可能导致老年人用药错误。药剂师可以通过开展用药评估来遏制这些错误的发生。老年人处方筛查工具(STOPP)或提醒医生正确治疗的筛查工具(START)可以通过提供关于何时应开始或停止特定类型药物治疗的指南,来遏制药物不良反应的发生率并提高用药合理性。本研究旨在评估使用STOPP/START来改善适应性用药合理性指数(MAI)、降低药物不良反应风险(老年医学网络评分)以及缩短住院时间(LOS)。印度尼西亚巴厘岛桑格拉总医院老年住院病房。对印度尼西亚巴厘岛一家三级医院住院部连续选取的60岁以上老年人进行了一项非随机对照试验。干预组接受药剂师与医生合作进行的用药评估,以便在入院时和住院期间根据STOPP/START标准评估用药合理性。对照组接受标准护理。使用适应性MAI、老年医学网络评分和住院时间来衡量结果。本研究纳入了干预组的30名患者和对照组的33名患者。适应性MAI分别为2.97(2.25)和9.94(6.14),P < 0.001。老年医学网络评分为3.33(2.28)和5.18(2.10),P = 0.003,住院时间分别为7.63(3.00)天和14.18(9.97)天,P = 0.011。使用STOPP/START作为用药评估工具可提高用药合理性,降低药物不良反应风险并缩短住院时间。

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