绿茶成分在乳腺癌预防和治疗中的作用
Green tea compounds in breast cancer prevention and treatment.
作者信息
Li Min-Jing, Yin Yan-Cun, Wang Jiao, Jiang Yang-Fu
机构信息
Min-Jing Li, Medicine and Pharmacy Research Center, Binzhou Medical University, Yantai 264003, Shandong Province, China.
出版信息
World J Clin Oncol. 2014 Aug 10;5(3):520-8. doi: 10.5306/wjco.v5.i3.520.
Breast cancer is the most common cancer among women. In recent years, many in vitro and in vivo studies indicate that green tea possesses anti-cancer effects. The epidemiological studies, however, have produced inconclusive results in humans. Likewise, results from animal models about the preventive or therapeutic effects of green tea components are inconclusive. The mechanisms by which green tea intake may influence the risk of breast cancer in humans remain elusive mechanisms by which green tea intake may influence. Here, we review recent studies of green tea polyphenols and their applications in the prevention and treatment of breast cancer. Furthermore, we discuss the effect of green tea components on breast cancer by reviewing epidemiological studies, animal model studies and clinical trials. At last, we discuss the mechanisms by which green tea components suppress the development and recurrence of breast cancer. A better understanding of the mechanisms will improve the utilization of green tea in breast cancer prevention and therapy and pave the way to novel prevention and treatment strategies for breast cancer.
乳腺癌是女性中最常见的癌症。近年来，许多体外和体内研究表明绿茶具有抗癌作用。然而，流行病学研究在人体上产生的结果尚无定论。同样，关于绿茶成分预防或治疗作用的动物模型研究结果也尚无定论。绿茶摄入可能影响人类患乳腺癌风险的机制仍然难以捉摸。在此，我们综述了绿茶多酚及其在乳腺癌预防和治疗中的应用的最新研究。此外，我们通过综述流行病学研究、动物模型研究和临床试验来讨论绿茶成分对乳腺癌的影响。最后，我们讨论绿茶成分抑制乳腺癌发生和复发的机制。对这些机制的更好理解将提高绿茶在乳腺癌预防和治疗中的利用率，并为乳腺癌的新型预防和治疗策略铺平道路。
Zotero 插件