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2
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本文引用的文献

1
EGCG attenuates high glucose-induced endothelial cell inflammation by suppression of PKC and NF-κB signaling in human umbilical vein endothelial cells.EGCG 通过抑制人脐静脉内皮细胞中的 PKC 和 NF-κB 信号通路来减轻高葡萄糖诱导的内皮细胞炎症。
Life Sci. 2013 Mar 21;92(10):589-97. doi: 10.1016/j.lfs.2013.01.025. Epub 2013 Feb 5.
2
Dietary regulation of histone acetylases and deacetylases for the prevention of metabolic diseases.饮食调控组蛋白乙酰转移酶和去乙酰化酶预防代谢性疾病。
Nutrients. 2012 Nov 28;4(12):1868-86. doi: 10.3390/nu4121868.
3
Cancer statistics, 2013.癌症统计数据，2013 年。
CA Cancer J Clin. 2013 Jan;63(1):11-30. doi: 10.3322/caac.21166. Epub 2013 Jan 17.
4
EGCG inhibits CTGF expression via blocking NF-κB activation in cardiac fibroblast.表没食子儿茶素没食子酸酯通过阻断 NF-κB 激活抑制心脏成纤维细胞中 CTGF 的表达。
Phytomedicine. 2013 Jan 15;20(2):106-13. doi: 10.1016/j.phymed.2012.10.002. Epub 2012 Nov 8.
5
Cancer chemoprevention with green tea catechins: from bench to bed.绿茶儿茶素的癌症化学预防：从实验室到病床。
Curr Drug Targets. 2012 Dec;13(14):1842-57. doi: 10.2174/138945012804545506.
6
Expression of NSAID-activated gene-1 by EGCG in head and neck cancer: involvement of ATM-dependent p53 expression.EGCG 通过 ATM 依赖性 p53 表达诱导头颈部癌细胞中 NSAID 激活基因-1 的表达。
J Nutr Biochem. 2013 Jun;24(6):986-99. doi: 10.1016/j.jnutbio.2012.07.003. Epub 2012 Sep 25.
7
DNA methyltransferases, DNA damage repair, and cancer.DNA 甲基转移酶、DNA 损伤修复与癌症。
Adv Exp Med Biol. 2013;754:3-29. doi: 10.1007/978-1-4419-9967-2_1.
8
Cancer chemoprevention and nutriepigenetics: state of the art and future challenges.癌症化学预防与营养表观遗传学：现状与未来挑战
Top Curr Chem. 2013;329:73-132. doi: 10.1007/128_2012_360.
9
Oxygen partial pressure modulates 67-kDa laminin receptor expression, leading to altered activity of the green tea polyphenol, EGCG.氧分压调节 67kDa 层粘连蛋白受体的表达，导致绿茶多酚 EGCG 活性改变。
FEBS Lett. 2012 Sep 21;586(19):3441-7. doi: 10.1016/j.febslet.2012.07.065. Epub 2012 Jul 31.
10
Laminin receptor specific therapeutic gold nanoparticles (198AuNP-EGCg) show efficacy in treating prostate cancer.层粘连蛋白受体特异性治疗金纳米颗粒（198AuNP-EGCg）在治疗前列腺癌方面显示出疗效。
Proc Natl Acad Sci U S A. 2012 Jul 31;109(31):12426-31. doi: 10.1073/pnas.1121174109. Epub 2012 Jul 16.

绿色行动：绿茶成分表没食子儿茶素没食子酸酯在化学预防中的作用

Going Green: The Role of the Green Tea Component EGCG in Chemoprevention.

作者信息

Schramm Laura

机构信息

Department of Biological Sciences, St. John's University, NY 11439, USA.

出版信息

J Carcinog Mutagen. 2013 May 20;4(142):1000142. doi: 10.4172/2157-2518.1000142.

DOI:10.4172/2157-2518.1000142
PMID:24077764
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3783360/
Abstract

Tea is one of the most consumed beverages worldwide, and green tea is the least processed from the buds of the plant. The most abundant component of green tea is (-)-epigallocatechin-3-gallate (EGCG), which has been the focus of many cell culture, animal and clinical trials, revealing that EGCG possesses antiproliferative, antimutagenic, antioxidant, antibacterial, antiviral and chemopreventive effects. In this review we briefly summarize the mechanism of action(s) of the green tea component EGCG, highlighting recent advances in the epigenetic regulation by EGCG. Additionally, we provide an overview of mouse chemoprevention studies and EGCG chemoprevention clinical trials.

摘要

茶是全球消费最为广泛的饮品之一，而绿茶是对茶树芽叶加工最少的茶类。绿茶中含量最为丰富的成分是（-）-表没食子儿茶素-3-没食子酸酯（EGCG），它一直是众多细胞培养、动物及临床试验的重点研究对象，这些研究表明EGCG具有抗增殖、抗诱变、抗氧化、抗菌、抗病毒及化学预防作用。在本综述中，我们简要总结了绿茶成分EGCG的作用机制，重点介绍了EGCG在表观遗传调控方面的最新进展。此外，我们还概述了小鼠化学预防研究及EGCG化学预防临床试验。