绿色行动：绿茶成分表没食子儿茶素没食子酸酯在化学预防中的作用
Going Green: The Role of the Green Tea Component EGCG in Chemoprevention.
作者信息
Schramm Laura
机构信息
Department of Biological Sciences, St. John's University, NY 11439, USA.
出版信息
J Carcinog Mutagen. 2013 May 20;4(142):1000142. doi: 10.4172/2157-2518.1000142.
Abstract
Tea is one of the most consumed beverages worldwide, and green tea is the least processed from the buds of the plant. The most abundant component of green tea is (-)-epigallocatechin-3-gallate (EGCG), which has been the focus of many cell culture, animal and clinical trials, revealing that EGCG possesses antiproliferative, antimutagenic, antioxidant, antibacterial, antiviral and chemopreventive effects. In this review we briefly summarize the mechanism of action(s) of the green tea component EGCG, highlighting recent advances in the epigenetic regulation by EGCG. Additionally, we provide an overview of mouse chemoprevention studies and EGCG chemoprevention clinical trials.
摘要
茶是全球消费最为广泛的饮品之一，而绿茶是对茶树芽叶加工最少的茶类。绿茶中含量最为丰富的成分是（-）-表没食子儿茶素-3-没食子酸酯（EGCG），它一直是众多细胞培养、动物及临床试验的重点研究对象，这些研究表明EGCG具有抗增殖、抗诱变、抗氧化、抗菌、抗病毒及化学预防作用。在本综述中，我们简要总结了绿茶成分EGCG的作用机制，重点介绍了EGCG在表观遗传调控方面的最新进展。此外，我们还概述了小鼠化学预防研究及EGCG化学预防临床试验。
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