Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology , Wuhan 430030, People's Republic of China.
J Nat Prod. 2017 Sep 22;80(9):2462-2471. doi: 10.1021/acs.jnatprod.7b00301. Epub 2017 Sep 12.
Eleven new alkaloids (1-11), classified as the 12-acetylplicamine (1), N-deformyl-seco-plicamine (2), plicamine (3-6), 4a-epi-plicamine (7), seco-plicamine (8), and lycorine (9-11) framework types, along with 15 known alkaloids (12-26) were isolated from the whole plants of Zephyranthes carinata. The structures of the new alkaloids 1-11 were established by extensive spectroscopic data interpretation. The absolute configurations of 9 and 10 were defined by single-crystal X-ray diffraction analysis. Zephycarinatines A (1), B (2), and G (7) represent the first examples of 12-acetylplicamine, N-deformyl-seco-plicamine, and 4a-epi-plicamine alkaloids, respectively. Alkaloids 6, 11, 17, and 20-23 exhibited AChE inhibitory activities with IC values ranging from 1.21 to 184.05 μM, and a preliminary structure-activity relationship is discussed.
从葱莲全株中分离得到 11 个新生物碱（1-11），分类为 12-乙酰基白屈菜红碱（1）、N-去甲变形白屈菜红碱（2）、白屈菜红碱（3-6）、4a-表白屈菜红碱（7）、白屈菜次碱（8）和石蒜碱（9-11）骨架类型，以及 15 个已知生物碱（12-26）。通过广泛的光谱数据分析，确定了新生物碱 1-11 的结构。通过单晶 X 射线衍射分析确定了 9 和 10 的绝对构型。Zephycarinatines A（1）、B（2）和 G（7）分别代表 12-乙酰基白屈菜红碱、N-去甲变形白屈菜红碱和 4a-表白屈菜红碱生物碱的第一个例子。生物碱 6、11、17、20-23 表现出 AChE 抑制活性，IC 值范围为 1.21-184.05 μM，并讨论了初步的结构-活性关系。
