Xin Ge, Yang Gao, Hui Liu
College of Medical Laboratory, Dalian Medical University, Dalian 116044, China.
Dalian Tuberculosis Hospital, China.
Diabetes Res Clin Pract. 2014 Oct;106(1):95-100. doi: 10.1016/j.diabres.2014.07.024. Epub 2014 Jul 29.
To observe the relationship among genes, obesity and the changes in serum glucose and lipid profile to assess whether obesity-related disease results from genes and/or obesity.
Correlations among serum glucose, lipids, waist circumference (WC), and Taq1B, I405V, and D442G polymorphisms of the cholesteryl ester transfer protein (CETP) gene were assessed. Logistic regression analysis was used to screen independent variables among obesity-related anthropometric indexes and serum biochemical indicators for genes.
The waist circumference density index (WCDI) may be attributed to changes in serum biochemical indicators and among WCDI, BMI and serum biochemical indicators, however, only WCDI was an independent variable for the G allele. Differences were observed in anthropometric indexes and serum biochemical indicators between subjects with the G allele and those without (p<0.05).
Abdominal obesity and changes in serum glucose and lipid profile are affected by a group of genes, including CETP. Correlation of the CETP gene with waist circumference may be independent compared with serum glucose and lipid profile.
观察基因、肥胖与血糖及血脂谱变化之间的关系，以评估肥胖相关疾病是否由基因和/或肥胖引起。
评估血清葡萄糖、脂质、腰围（WC）与胆固醇酯转运蛋白（CETP）基因的Taq1B、I405V和D442G多态性之间的相关性。采用逻辑回归分析在肥胖相关人体测量指标和血清生化指标中筛选基因的独立变量。
腰围密度指数（WCDI）可能归因于血清生化指标的变化，在WCDI、BMI和血清生化指标中，然而，只有WCDI是G等位基因的独立变量。携带G等位基因的受试者与未携带G等位基因的受试者在人体测量指标和血清生化指标上存在差异（p<0.05）。
腹部肥胖以及血糖和血脂谱的变化受一组基因影响，包括CETP。与血糖和血脂谱相比，CETP基因与腰围的相关性可能是独立的。
