埃及代谢综合征患者中胆固醇酯转运蛋白（CETP）的Taq1B多态性
Taq1B polymorphism of cholesteryl ester transfer protein (CETP) in Egyptian patients with metabolic syndrome.
作者信息
Elsammak Mohamed Y, Al-Sharkaweey Rania M, Fahmy Mohamed, Reda Ahmed A, Farid Walla, Emara Ahmed, Hassan Hesham, Kandil Mona H
机构信息
Department of Chemical Pathology, Medical Research Institute teaching Hospital, Alexandria University, Egypt.
出版信息
Diabetes Metab Syndr. 2011 Apr-Jun;5(2):61-5. doi: 10.1016/j.dsx.2010.12.009. Epub 2010 Dec 30.
AIM
We aimed at evaluation of the possible association of cholesteryl ester transfer protein (CETP) Taq1B polymorphism with the components of metabolic syndrome in a cohort of Egyptian patients compared to their healthy counterparts.
PATIENTS AND METHODS
Blood samples were collected for lipid profile, fasting glucose, insulin and routine biochemical tests. The Taq1B genotypes of CETP were determined using RFLP-PCR technique.
RESULTS
The patients group showed a significantly higher B1B1 genotype and lower B2B2 genotype compared to the controls group. Serum HDL-C level was significantly higher in all subjects with the B2B2 genotype compared to those with B1B1 genotype. In the patients group, age positively correlated with cholesterol level, triglycerides, BMI and waist circumference.
CONCLUSION
Egyptian patients affected with metabolic syndrome have a higher prevalence of B1B1 genotype that is associated with lower serum HDL-C levels.
目的
我们旨在评估埃及患者队列中胆固醇酯转运蛋白（CETP）Taq1B基因多态性与代谢综合征各组分之间可能存在的关联，并与健康对照者进行比较。
患者与方法
采集血样用于血脂谱、空腹血糖、胰岛素及常规生化检测。采用限制性片段长度多态性聚合酶链反应（RFLP-PCR）技术测定CETP的Taq1B基因型。
结果
与对照组相比，患者组B1B1基因型显著更高，B2B2基因型更低。与B1B1基因型的所有受试者相比，B2B2基因型的所有受试者血清高密度脂蛋白胆固醇（HDL-C）水平显著更高。在患者组中，年龄与胆固醇水平、甘油三酯、体重指数（BMI）和腰围呈正相关。
结论
患有代谢综合征的埃及患者中B1B1基因型的患病率更高，该基因型与较低的血清HDL-C水平相关。
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