Emamian Marzieh, Avan Amir, Pasdar Alireza, Mirhafez Seyed Reza, Sadeghzadeh Mahsa, Moghadam Masoud Saleh, Parizadeh Seyed Mohammad Reza, Ferns Gordon A, Ghayour-Mobarhan Majid
Department of New Science and Technologies, Cardiovascular Research Center, Biochemistry of Nutrition Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran; Department of Biochemistry, Faculty of Science, Payame Noor University, Mashhad, Iran.
Department of New Science and Technologies, Cardiovascular Research Center, Biochemistry of Nutrition Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran; Department of Medical Oncology, VU University Medical Center, Amsterdam, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands.
Gene. 2015 Mar 10;558(2):195-9. doi: 10.1016/j.gene.2014.12.070. Epub 2015 Jan 9.
Obesity is often associated with an alter lipid profile, e.g., raised serum triglycerides (TG) and low high-density lipoprotein (HDL) cholesterol levels, both important risk factor for cardiovascular-diseases. The aim of current study was to explore the association of a polymorphism of the lipoprotein lipase (LPL) rs328 and cholesteryl-ester-transfer-protein (CETP) rs5882 genes in relation to lipid profile in subjects with/without obesity.
SUBJECTS/METHODS: Genotyping was carried out in 271 individuals, (151 obese subjects and 120 non-obese). Univariate/multivariate analyses were conducted to evaluate the association of these genetic-polymorphisms with obesity and lipid components.
Obese subjects had a significantly (P<0.05) higher level of triglyceride (TG), blood pressure, waist-circumference and fasting-blood-glucose, and lower level of HDL-C. LPL and CETP polymorphisms were not associated with obesity in our population. However, the LPL rs328-GG-GC genotype was significantly related to a higher concentration of TG, compared to the CC wild-type; and a higher HDL-C level in the obesity-group with respect to the control group. Moreover, obese-subjects carrying the G allele of CETP had a significantly lower level of HDL-C (P<0.05) compared to those with C allele.
We demonstrate a significant association of LPL and CETP polymorphisms with serum triglycerides and HDL-cholesterol.
肥胖常与脂质谱改变相关，例如血清甘油三酯（TG）升高和高密度脂蛋白（HDL）胆固醇水平降低，这两者都是心血管疾病的重要危险因素。本研究的目的是探讨脂蛋白脂肪酶（LPL）rs328和胆固醇酯转运蛋白（CETP）rs5882基因多态性与肥胖或非肥胖受试者脂质谱的关系。
受试者/方法：对271名个体（151名肥胖受试者和120名非肥胖受试者）进行基因分型。进行单因素/多因素分析以评估这些基因多态性与肥胖和脂质成分的关联。
肥胖受试者的甘油三酯（TG）水平、血压、腰围和空腹血糖显著（P<0.05）升高，HDL-C水平降低。在我们的人群中，LPL和CETP多态性与肥胖无关。然而，与CC野生型相比，LPL rs328-GG-GC基因型与更高的TG浓度显著相关；并且在肥胖组中相对于对照组HDL-C水平更高。此外，携带CETP G等位基因的肥胖受试者与携带C等位基因的受试者相比，HDL-C水平显著更低（P<0.05）。
我们证明LPL和CETP多态性与血清甘油三酯和HDL胆固醇显著相关。
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