Departamento de Biología Molecular y Genómica, Instituto de Nutrigenética y Nutrigenómica Traslacional, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, Mexico.
Departamento de Biología Molecular y Genómica, Doctorado en Ciencias en Biología Molecular en Medicina, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, Mexico.
Lifestyle Genom. 2023;16(1):83-89. doi: 10.1159/000529053. Epub 2023 Jan 18.
Obesity is a prevalent multifactorial disease whose main complication is dyslipidemia. Serum lipid levels also depend on genetic factors including the Taq1B variant of the CETP gene, which is suggested to be influenced by environmental factors and adiposity. Therefore, this study aimed to determine the effect of the Taq1B CETP variant on serum lipid levels associated with anthropometrical variables.
165 women from western Mexico were enrolled in this cross-sectional study. Weight and body fat were measured by bioimpedance and waist circumference with a measuring tape. Serum lipid levels were determined by dry chemistry. The Taq1B CETP variant was analyzed by allelic discrimination.
Women with abdominal obesity and the B1B2/B2B2 genotype had significantly higher total cholesterol levels (195.17 [185.95-204.39] vs. 183 mg/dL [169.83-196.16], p = 0.007) and low density lipoprotein (118.84 [110.65-127.03] vs. 113.84 mg/dL [102.37-125.31], p = 0.037) than carriers of the B1B1 genotype. Likewise, subjects with excessive adiposity and the B1B2/B2B2 genotype showed significantly higher total cholesterol levels (195.05 [186.04-204.06] vs. 182.40 mg/dL [169.03-195.76], p = 0.003) than those with the B1B1 genotype.
Women with abdominal obesity or excessive adiposity, who are also carriers of the B1B2/B2B2 genotype, have higher serum lipid levels than women with the B1B1 genotype.
肥胖是一种普遍的多因素疾病，其主要并发症是血脂异常。血清脂质水平也取决于遗传因素，包括 CETP 基因的 Taq1B 变体，该变体被认为受环境因素和肥胖的影响。因此，本研究旨在确定 Taq1B CETP 变体对与人体测量变量相关的血清脂质水平的影响。
本横断面研究纳入了来自墨西哥西部的 165 名女性。体重和体脂肪通过生物阻抗法和测径规测量，腰围通过测径规测量。血清脂质水平通过干化学法测定。Taq1B CETP 变体通过等位基因鉴别分析。
患有腹型肥胖和 B1B2/B2B2 基因型的女性总胆固醇水平显著升高（195.17 [185.95-204.39] 与 183 mg/dL [169.83-196.16]，p=0.007）和低密度脂蛋白（118.84 [110.65-127.03] 与 113.84 mg/dL [102.37-125.31]，p=0.037）比 B1B1 基因型携带者更高。同样，超重和 B1B2/B2B2 基因型的受试者总胆固醇水平也显著升高（195.05 [186.04-204.06] 与 182.40 mg/dL [169.03-195.76]，p=0.003）比 B1B1 基因型携带者更高。
携带 B1B2/B2B2 基因型的腹型肥胖或超重女性的血清脂质水平高于携带 B1B1 基因型的女性。
