Isoda K, Takagi Y, Endo K, Miyaki M, Matsuo K, Umeda K, Umeda-Togami K, Mizutani H
Department of Dermatology, Mie University Graduate School of Medicine, Mie, Japan.
Skin Res Technol. 2015 May;21(2):247-53. doi: 10.1111/srt.12183. Epub 2014 Aug 13.
BACKGROUND/PURPOSE: Washing the face with a mild cleanser is generally recommended for acne care. Occasionally, the general public has the misconception that acne is exacerbated by cleansers and furthermore it has concerns about inducing skin irritation and xerosis by intensive washing. Recently, we developed a new cleanser based on sodium laureth carboxylate and alkyl carboxylates (AEC/soap) that cleans sebum well without penetrating the stratum corneum.
We designed a controlled clinical trial conducted on adult Japanese males with moderate or less acne. Twenty subjects washed their faces with AEC/soap base cleanser twice a day for 4 weeks. Assessment of the efficacy was conducted prior to the start of the study, and at the end of weeks 2 and 4.
Significant improvement of the acne was observed within 2 weeks, and acne lesions were not detectable in 25% of the subjects at week 4. Sebum secretion levels on the skin significantly increased on the forehead, but significantly decreased on the cheek which correlated with the improvement. No complaints of dryness or irritation occurred during the study.
Washing the face twice a day with facial cleanser based on AEC/soap is an effective care for moderate or less grade facial acne.
背景/目的：一般建议使用温和洁面产品洗脸来护理痤疮。偶尔，普通大众存在一种误解，认为洁面产品会加重痤疮，而且担心过度清洁会导致皮肤刺激和干燥。最近，我们研发了一种基于月桂醇聚醚羧酸钠和烷基羧酸盐（AEC/皂基）的新型洁面产品，它能有效清洁皮脂且不会渗透角质层。
我们设计了一项针对轻度至中度痤疮成年日本男性的对照临床试验。20名受试者每天使用AEC/皂基洁面产品洗脸两次，持续4周。在研究开始前、第2周和第4周结束时进行疗效评估。
2周内观察到痤疮有显著改善，第4周时25%的受试者痤疮皮损不可见。前额皮肤皮脂分泌水平显著增加，但脸颊上的皮脂分泌水平显著下降，这与改善情况相关。研究期间未出现干燥或刺激的主诉。
每天使用基于AEC/皂基的洁面产品洗脸两次，对轻度至中度面部痤疮是一种有效的护理方法。
