原条中的交通堵塞：中胚层迁移缺陷在出生缺陷中的作用。
Traffic jam in the primitive streak: the role of defective mesoderm migration in birth defects.
作者信息
Herion Nils J, Salbaum J Michael, Kappen Claudia
机构信息
Pennington Biomedical Research Center, Department of Developmental Biology, Baton Rouge, Louisiana.
出版信息
Birth Defects Res A Clin Mol Teratol. 2014 Aug;100(8):608-22. doi: 10.1002/bdra.23283. Epub 2014 Aug 13.
Abstract
Gastrulation is the process in which the three germ layers are formed that contribute to the formation of all major tissues in the developing embryo. We here review mouse genetic models in which defective gastrulation leads to mesoderm insufficiencies in the embryo. Depending on severity of the abnormalities, the outcomes range from incompatible with embryonic survival to structural birth defects, such as heart defects, spina bifida, or caudal dysgenesis. The combined evidence from the mutant models supports the notion that these congenital anomalies can originate from perturbations of mesoderm specification, epithelial-mesenchymal transition, and mesodermal cell migration. Knowledge about the molecular pathways involved may help to improve strategies for the prevention of major structural birth defects.
摘要
原肠胚形成是一个过程，在此过程中形成了三个胚层，它们有助于发育中的胚胎形成所有主要组织。我们在此回顾小鼠遗传模型，其中原肠胚形成缺陷会导致胚胎中胚层不足。根据异常的严重程度，结果从胚胎无法存活到结构性出生缺陷，如心脏缺陷、脊柱裂或尾部发育不全。来自突变模型的综合证据支持了这样一种观点，即这些先天性异常可能源于中胚层特化、上皮-间充质转化和中胚层细胞迁移的扰动。对所涉及分子途径的了解可能有助于改进预防主要结构性出生缺陷的策略。
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