Santos Itamar S, Goulart Alessandra C, Passos Valeria M, Molina Maria del Carmen, Lotufo Paulo A, Bensenor Isabela M
Faculdade de Medicina da Universidade de São Paulo, Brazil Centro de Pesquisa Clínica e Epidemiológica do Hospital Universitário da Universidade de São Paulo, Brazil
Centro de Pesquisa Clínica e Epidemiológica do Hospital Universitário da Universidade de São Paulo, Brazil Divisão de Clínica Médica do Hospital Universitário da Universidade de São Paulo, Brazil.
Cephalalgia. 2015 Apr;35(5):426-36. doi: 10.1177/0333102414544978. Epub 2014 Aug 12.
Most studies assessing the association between migraine and obesity have shown conflicting results. We aimed to evaluate the association between obesity and migraine in ELSA-Brasil, a cohort study of 15,105 individuals aged 35-74 years.
We assessed migraine using a validated questionnaire based on International Headache Society criteria and anthropometric measurements using standard techniques. Migraine was categorized as daily and non-daily. World Health Organization criteria were used to categorize overweight, obesity and abdominal obesity (AbO). We performed a cross-sectional analysis using multivariate logistic regression models to study the association between migraine and obesity (body mass index (BMI) ≥ 30 kg/m(2)), compared to controls without migraine.
We found an association between daily migraine and obesity (odds ratio (OR) 1.86; 95% confidence interval (95% CI): 1.12-3.09). Although the presence of AbO was not associated with migraine, interaction models showed that the association between obesity and daily migraine remained strong only in the absence of AbO diagnosis, notably in individuals aged 35-49 years.
In our large sample of individuals aged 35 years or older, obesity, but not AbO, was associated with daily migraine. AbO influenced the association between BMI and daily migraine in migraineurs aged 35-49 years.
大多数评估偏头痛与肥胖之间关联的研究结果相互矛盾。我们旨在评估巴西老年人健康与生活方式研究（ELSA - Brasil）中肥胖与偏头痛之间的关联，该队列研究涵盖了15105名年龄在35 - 74岁之间的个体。
我们使用基于国际头痛协会标准的有效问卷评估偏头痛，并采用标准技术进行人体测量。偏头痛分为每日发作型和非每日发作型。世界卫生组织标准用于对超重、肥胖和腹型肥胖（AbO）进行分类。我们使用多变量逻辑回归模型进行横断面分析，以研究偏头痛与肥胖（体重指数（BMI）≥30 kg/m²）之间的关联，并与无偏头痛的对照组进行比较。
我们发现每日发作型偏头痛与肥胖之间存在关联（优势比（OR）为1.86；95%置信区间（95%CI）：1.12 - 3.09）。虽然腹型肥胖的存在与偏头痛无关，但交互模型显示，仅在未诊断为腹型肥胖的情况下，肥胖与每日发作型偏头痛之间的关联仍然很强，特别是在35 - 49岁的个体中。
在我们这个由35岁及以上个体组成的大样本中，肥胖而非腹型肥胖与每日发作型偏头痛相关。腹型肥胖影响了35 - 49岁偏头痛患者中BMI与每日发作型偏头痛之间的关联。
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