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[苏司他尼与其他剂型硝酸盐药物抗心绞痛疗效的评估]

[Evaluation of the antianginal efficacy of sustonit compared with other nitrate drug forms].

作者信息

Metelitsa V I, Kokurina E V, Martsevich S Iu, Urumbaev R K, Slastnikova I D

出版信息

Ter Arkh. 1989;61(8):27-30.

PMID:2511641
Abstract

Sustonite, a long-acting nitroglycerin drug for oral use (manufactured in Poland), and some other dosage forms of nitrates were studied and compared. Twenty-one patients with stable angina pectoris of effort, functional classes II-III, were entered into the study. Sustonite was shown to produce an antianginal effect slightly yielding to that of sustac administered in equivalent doses. As to the effectiveness, sustonite appeared inferior to the dosage forms of nitrates such as nitrosorbide tablets, trinitrolong and dinitrosorbilong plates. The effect of sustonite manifested itself much later than that of sustac. As regards the physicochemical properties, sustonite tablets materially differ from sustac tablets in disintegration and solubility which are worse. The content of nitroglycerin in the tablets has turned out lower (1.2-1.4-fold) as compared to that indicated by the manufacturer.

摘要

舒斯顿尼特(一种波兰生产的长效口服硝酸甘油药物)以及其他一些剂型的硝酸盐进行了研究和比较。21例功能性II - III级的劳力性稳定型心绞痛患者参与了该研究。结果表明,舒斯顿尼特产生的抗心绞痛作用略逊于等量服用的舒他克。在有效性方面,舒斯顿尼特似乎不如硝酸异山梨酯片、长效硝酸甘油和双硝酸异山梨酯片等硝酸盐剂型。舒斯顿尼特的作用比舒他克出现得晚得多。在物理化学性质方面,舒斯顿尼特片在崩解和溶解性上与舒他克片有很大不同,且更差。片剂中硝酸甘油的含量比制造商标注的低(低1.2 - 1.4倍)。

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