Pommery J, Lhermitte M
Laboratoire de Toxicologie, Faculte de Pharmacie, Lille, France.
Biomed Chromatogr. 1989 Jul;3(4):177-9. doi: 10.1002/bmc.1130030408.
A method has been developed for the separation and measurement of fluvoxamine in human plasma by high performance liquid chromatography. The method uses metapramine as an internal standard and provides a limit of detection of about 1.5 ng/mL for fluvoxamine. At a concentration of 25 ng/mL, fluvoxamine could be measured within a coefficient of variation of +/- 5.82 of the mean and at 100 ng/mL within a CV of +/- 2.78 of the mean. The method has been applied to the analysis of plasma from patients undergoing fluvoxamine therapy.
已开发出一种通过高效液相色谱法分离和测定人血浆中氟伏沙明的方法。该方法使用间普拉明作为内标，氟伏沙明的检测限约为1.5 ng/mL。在浓度为25 ng/mL时，氟伏沙明的测量变异系数在平均值的±5.82范围内；在100 ng/mL时，变异系数在平均值的±2.78范围内。该方法已应用于接受氟伏沙明治疗患者的血浆分析。
