远距离基因调控：高级染色质折叠和表皮分化复合物基因座转录的协调控制。
Gene regulation at a distance: higher-order chromatin folding and the coordinated control of gene transcription at the epidermal differentiation complex locus.
机构信息
Centre for Skin Sciences and School of Medical Sciences, School of Life Sciences, University of Bradford, Bradford, UK.
出版信息
J Invest Dermatol. 2014 Sep;134(9):2307-2310. doi: 10.1038/jid.2014.247.
PMID:25120147
Abstract
Chromatin structure and spatial interactions between proximal and distal gene regulatory elements, including gene core promoters and enhancers, are important in the control of gene transcription. In this issue, Oh et al. characterized an AP-1-dependent enhancer at the epidermal differentiation complex locus that establishes spatial interactions with numerous gene promoter regions at that locus.
摘要
染色质结构和近端与远端基因调控元件（包括基因核心启动子和增强子）之间的空间相互作用，对于基因转录的控制非常重要。在本期杂志中，Oh 等人研究了表皮分化复合体基因座上的一个依赖于 AP-1 的增强子，该增强子与该基因座上的许多基因启动子区域建立了空间相互作用。
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