18F-氟代脱氧葡萄糖正电子发射断层扫描/计算机断层扫描最大标准化摄取值与葡萄糖转运蛋白-1 表达与胰腺浸润性导管癌的生存相关。

Maximum standardized uptake value on 18F-fluoro-2-deoxy-glucose positron emission tomography/computed tomography and glucose transporter-1 expression correlates with survival in invasive ductal carcinoma of the pancreas.

机构信息

From the Departments of *Surgery, †Internal Medicine (Division of Gastroenterology), ‡Hospital Pathology, and §Radiology, Kurume University School of Medicine, Kurume, Japan.

出版信息

Pancreas. 2014 Oct;43(7):1060-5. doi: 10.1097/MPA.0000000000000185.

DOI:10.1097/MPA.0000000000000185

PMID:25121413

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4175014/

Abstract

OBJECTIVES

The purpose of this study was to assess the correlations among the maximum standardized uptake value (SUVmax) on 18F-fluoro-2-deoxy-glucose positron emission tomography/computed tomography (FDG-PET/CT); the expressions of glucose transporter 1 (GLUT-1), glucose transporter 3, and epidermal growth factor receptor (EGFR); as well as prognosis in patients with invasive ductal carcinoma of the pancreas.

METHODS

A total of 41 patients with surgically resected and histologically proven invasive ductal carcinoma of the pancreas who underwent preoperative FDG-PET/CT were assessed. The SUVmax at the primary tumor site was measured by FDG-PET/CT, and immunohistochemical staining of tumor sections was performed for GLUT-1, glucose transporter 3, and EGFR.

RESULTS

Higher FDG uptake (SUVmax, >3.40) and GLUT-1 expression were significantly associated with shorter overall survival (P < 0.05). The SUVmax was not found to be significantly correlated with clinicopathological characteristics such as TNM classification, lymph node metastasis, and tumor differentiation. The EGFR expression was significantly correlated with the SUVmax (P = 0.024).

CONCLUSIONS

Higher FDG uptake and GLUT-1 expression in invasive ductal carcinoma of the pancreas seems to be an important prognostic factor. In addition, the EGFR expression was significantly correlated with the SUVmax.

摘要