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1
Small molecule adenosine 5'-monophosphate activated protein kinase (AMPK) modulators and human diseases.
J Med Chem. 2015 Jan 8;58(1):2-29. doi: 10.1021/jm401994c. Epub 2014 Aug 28.
2
AMP-activated protein kinase: a key regulator of energy balance with many roles in human disease.
J Intern Med. 2014 Dec;276(6):543-59. doi: 10.1111/joim.12268. Epub 2014 May 27.
3
Structure of mammalian AMPK and its regulation by ADP.
Nature. 2011 Apr 14;472(7342):230-3. doi: 10.1038/nature09932. Epub 2011 Mar 13.
5
Allosteric regulation of AMP-activated protein kinase by adenylate nucleotides and small-molecule drugs.
Biochem Soc Trans. 2019 Apr 30;47(2):733-741. doi: 10.1042/BST20180625. Epub 2019 Apr 18.
6
AMPK signalling in health and disease.
Curr Opin Cell Biol. 2017 Apr;45:31-37. doi: 10.1016/j.ceb.2017.01.005. Epub 2017 Feb 21.
8
AMPK is a direct adenylate charge-regulated protein kinase.
Science. 2011 Jun 17;332(6036):1433-5. doi: 10.1126/science.1200094.
10
LKB1 and AMP-activated protein kinase control of mTOR signalling and growth.
Acta Physiol (Oxf). 2009 May;196(1):65-80. doi: 10.1111/j.1748-1716.2009.01972.x. Epub 2009 Feb 19.

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Development of novel osteoarthritis therapy by targeting AMPK-β-catenin-Runx2 signaling.
Genes Dis. 2024 Feb 24;12(1):101247. doi: 10.1016/j.gendis.2024.101247. eCollection 2025 Jan.
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Immunometabolism in cancer: basic mechanisms and new targeting strategy.
Cell Death Discov. 2024 May 16;10(1):236. doi: 10.1038/s41420-024-02006-2.
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Extract of Inhibits Lipid Accumulation in In Vitro and In Vivo by Regulating Oxidative Stress.
Antioxidants (Basel). 2023 Jul 14;12(7):1426. doi: 10.3390/antiox12071426.
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Characterization and Comparison of the Divergent Metabolic Consequences of High-Sugar and High-Fat Diets in Male Wistar Rats.
Front Physiol. 2022 Jul 4;13:904366. doi: 10.3389/fphys.2022.904366. eCollection 2022.
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The Role of AMP-activated Protein Kinase in Oxytosis/Ferroptosis: Protector or Potentiator?
Antioxid Redox Signal. 2024 Dec;41(16-18):e1173-e1186. doi: 10.1089/ars.2022.0013. Epub 2022 Apr 8.
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Research Progress on Oxidative Stress and Its Nutritional Regulation Strategies in Pigs.
Animals (Basel). 2021 May 13;11(5):1384. doi: 10.3390/ani11051384.
8
Hyperbaric oxygen promotes mitophagy by activating CaMKK/AMPK signal pathway in rats of neuropathic pain.
Mol Pain. 2019 Jan-Dec;15:1744806919871381. doi: 10.1177/1744806919871381.
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AMPK activation by AICAR sensitizes prostate cancer cells to radiotherapy.
Oncotarget. 2019 Jan 22;10(7):749-759. doi: 10.18632/oncotarget.26598.

本文引用的文献

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Discovery of Pyridones As Oral AMPK Direct Activators.
ACS Med Chem Lett. 2013 May 17;4(7):632-6. doi: 10.1021/ml400157g. eCollection 2013 Jul 11.
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Development of Novel Alkene Oxindole Derivatives As Orally Efficacious AMP-Activated Protein Kinase Activators.
ACS Med Chem Lett. 2013 Mar 25;4(5):475-80. doi: 10.1021/ml400028q. eCollection 2013 May 9.
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A Potent and Selective AMPK Activator That Inhibits de Novo Lipogenesis.
ACS Med Chem Lett. 2010 Aug 30;1(9):478-82. doi: 10.1021/ml100143q. eCollection 2010 Dec 9.
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Sorafenib as first- or second-line therapy in patients with metastatic renal cell carcinoma in a community setting.
Future Oncol. 2014 Aug;10(10):1741-50. doi: 10.2217/fon.14.48. Epub 2014 Mar 18.
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Exercise performance and peripheral vascular insufficiency improve with AMPK activation in high-fat diet-fed mice.
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Regorafenib in metastatic colorectal cancer.
Expert Rev Anticancer Ther. 2014 Mar;14(3):255-65. doi: 10.1586/14737140.2014.894887.
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Resveratrol, an activator of SIRT1, upregulates AMPK and improves cardiac function in heart failure.
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A novel direct activator of AMPK inhibits prostate cancer growth by blocking lipogenesis.
EMBO Mol Med. 2014 Apr;6(4):519-38. doi: 10.1002/emmm.201302734. Epub 2014 Feb 4.
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De novo fatty acid synthesis at the mitotic exit is required to complete cellular division.
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Structural basis of AMPK regulation by small molecule activators.
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