Jayapal N, Shanmugasundaram N, Thomas P A, Valli P R, Thyagarajan S P, Subramanian S
Indian J Pathol Microbiol. 1989 Jan;32(1):33-9.
Immune Complexes are involved in the Pathogenesis of many diseases of varied aetiology such as autoimmune disorders, protozoal diseases, bacterial and viral infections. Quantitation of immune Complexes in these diseases can be used for diagnosis and to ascertain the prognosis. The simple method of precipitation by polyethylene glycol and quantitation by single Radial Immunodiffusion has been used in leprosy, syphilis, bacterial endocarditis and systemic lupus erythematosus (SLE). This method found significantly higher levels of circulating immune complexes (CICs) in erythema nodosum leprosum, culture positive bacterial endocarditis and SLE where CICs are known to play an important role in the pathogenesis.
免疫复合物参与多种病因各异的疾病的发病机制，如自身免疫性疾病、原生动物疾病、细菌和病毒感染。对这些疾病中的免疫复合物进行定量可用于诊断并确定预后。通过聚乙二醇沉淀及单向放射免疫扩散定量的简单方法已应用于麻风病、梅毒、细菌性心内膜炎和系统性红斑狼疮（SLE）。该方法发现在结节性红斑型麻风、培养阳性的细菌性心内膜炎和SLE中循环免疫复合物（CICs）水平显著更高，而在这些疾病中CICs已知在发病机制中起重要作用。
