KLK11信使核糖核酸表达预示着结肠腺癌患者无病生存期和总生存期较差。
KLK11 mRNA expression predicts poor disease-free and overall survival in colorectal adenocarcinoma patients.
作者信息
Alexopoulou Dimitra K, Kontos Christos K, Christodoulou Spyridon, Papadopoulos Iordanis N, Scorilas Andreas
机构信息
Department of Biochemistry & Molecular Biology, University of Athens, Panepistimiopolis, 15701, Athens, Greece.
出版信息
Biomark Med. 2014;8(5):671-85. doi: 10.2217/bmm.13.151.
BACKGROUND
Dysregulated expression of several KLK family members has been observed in colorectal adenocarcinoma. In the present study, the prognostic value of KLK11 mRNA expression as a molecular tissue biomarker in colorectal adenocarcinoma was examined.
MATERIALS & METHODS: Using quantitative real-time PCR, KLK11 mRNA expression was studied in 120 cancerous and 41 paired noncancerous colorectal specimens obtained from 120 patients with primary colorectal adenocarcinoma.
RESULTS
A significant upregulation of KLK11 transcripts in colorectal tumors was observed. KLK11 mRNA expression was associated with the depth of tumor invasion and the histological grade. Furthermore, KLK11 mRNA expression predicted poor disease-free and overall survival, independently of patient gender, age, tumor size, location, histological subtype, grade, venous invasion, lymphatic invasion, TNM stage, radiotherapy and chemotherapy treatment.
CONCLUSION
KLK11 mRNA expression could be considered as a new molecular prognostic biomarker in colorectal adenocarcinoma, with additional prognostic value in patients with highly invasive tumors and/or positive lymph nodes.
背景
在结肠直肠癌中已观察到几种激肽释放酶（KLK）家族成员的表达失调。在本研究中，检测了KLK11 mRNA表达作为结肠直肠癌分子组织生物标志物的预后价值。
材料与方法
使用定量实时PCR，对120例原发性结肠直肠癌患者的120个癌性和41对配对的非癌性结肠直肠标本中的KLK11 mRNA表达进行了研究。
结果
观察到结肠直肠肿瘤中KLK11转录本显著上调。KLK11 mRNA表达与肿瘤浸润深度和组织学分级相关。此外，KLK11 mRNA表达预测无病生存期和总生存期较差，与患者性别、年龄、肿瘤大小、位置、组织学亚型、分级、静脉侵犯、淋巴侵犯、TNM分期、放疗和化疗治疗无关。
结论
KLK11 mRNA表达可被视为结肠直肠癌中的一种新的分子预后生物标志物，对高侵袭性肿瘤和/或阳性淋巴结患者具有额外的预后价值。
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