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一种产生多种细胞因子并形成快速进展的肿块样混浊的肺多形性癌。

A pleomorphic carcinoma of the lung producing multiple cytokines and forming a rapidly progressive mass-like opacity.

作者信息

Matsumoto Masataka, Nakayama Takashi, Inoue Daiki, Takamatsu Kazufumi, Itotani Ryo, Ishitoko Manabu, Suzuki Shinko, Sakuramoto Minoru, Yuba Yoshiaki, Yoshie Osamu, Takemura Masaya, Fukui Motonari

机构信息

Division of Respiratory Medicine, Kita-Harima Medical Center, Ono, Japan.

出版信息

BMC Cancer. 2014 Aug 13;14:588. doi: 10.1186/1471-2407-14-588.

DOI:10.1186/1471-2407-14-588
PMID:25123545
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4141101/
Abstract

BACKGROUND

Lung cancer cells have been reported to produce cytokines, resulting in systemic reactions. There have been few reports showing that these cytokines induced the formation of an inflammatory mass around lung cancers.

CASE PRESENTATION

We encountered a patient with a pleomorphic carcinoma of the lung. This tumor produced interleukin (IL)-8, granulocyte colony-stimulating factor and IL-6, which in turn recruited inflammatory cells, such as CD8 positive lymphocytes, around the tumor, resulting in a rapidly growing tumor shadow.

CONCLUSION

18 F-fluoro-deoxy-glucose positron emission tomography, in addition to a conventional radiological approach such as computed tomography, may detect immunological responses around a tumor.

摘要

背景

据报道，肺癌细胞会产生细胞因子，从而引发全身反应。鲜有报道表明这些细胞因子会诱导肺癌周围形成炎性肿块。

病例报告

我们遇到一名患有肺多形性癌的患者。该肿瘤产生白细胞介素（IL）-8、粒细胞集落刺激因子和IL-6，进而在肿瘤周围募集炎性细胞，如CD8阳性淋巴细胞，导致肿瘤阴影迅速增大。

结论

除计算机断层扫描等传统放射学方法外，18F-氟脱氧葡萄糖正电子发射断层扫描可能检测到肿瘤周围的免疫反应。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cc4a/4141101/7d301b917b74/12885_2014_4774_Fig10_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cc4a/4141101/a007cddce7cc/12885_2014_4774_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cc4a/4141101/46b2a687ac2d/12885_2014_4774_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cc4a/4141101/2f3df1ee52d3/12885_2014_4774_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cc4a/4141101/822b163864fe/12885_2014_4774_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cc4a/4141101/d55d32d1da77/12885_2014_4774_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cc4a/4141101/ce2a15539f9a/12885_2014_4774_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cc4a/4141101/1c91e596e4ec/12885_2014_4774_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cc4a/4141101/f483a661c27b/12885_2014_4774_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cc4a/4141101/271d28a25a40/12885_2014_4774_Fig9_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cc4a/4141101/7d301b917b74/12885_2014_4774_Fig10_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cc4a/4141101/a007cddce7cc/12885_2014_4774_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cc4a/4141101/46b2a687ac2d/12885_2014_4774_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cc4a/4141101/2f3df1ee52d3/12885_2014_4774_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cc4a/4141101/822b163864fe/12885_2014_4774_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cc4a/4141101/d55d32d1da77/12885_2014_4774_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cc4a/4141101/ce2a15539f9a/12885_2014_4774_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cc4a/4141101/1c91e596e4ec/12885_2014_4774_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cc4a/4141101/f483a661c27b/12885_2014_4774_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cc4a/4141101/271d28a25a40/12885_2014_4774_Fig9_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cc4a/4141101/7d301b917b74/12885_2014_4774_Fig10_HTML.jpg

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