• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

伴有提示上皮-间质转化的肉瘤样改变的粒细胞集落刺激因子和白细胞介素-6分泌性肺大细胞癌：一例尸检病例报告

Granulocyte Colony-stimulating Factor- and Interleukin-6-producing Large-cell Carcinoma of the Lung with Sarcomatoid Changes Suggestive of Epithelial-mesenchymal Transition: An Autopsy Case Report.

作者信息

Yoshida Yukinari, Sibusa Takashi, Ishii Yoshifumi, Akino Kimishige, Kikuchi Takefumi, Mita Hiroaki, Adachi Yasuyo, Nakamura Masahiro, Adachi Yasushi, Kato Yasuo, Endo Takao

机构信息

Department of Internal Medicine and Gastroenterology, Sapporo Shirakabadai Hospital, Japan.

Department of Respiratory Medicine, Sapporo Shirakabadai Hospital, Japan.

出版信息

Intern Med. 2019 Nov 15;58(22):3305-3311. doi: 10.2169/internalmedicine.2819-19. Epub 2019 Jul 31.

DOI:10.2169/internalmedicine.2819-19
PMID:31366794
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6911748/
Abstract

A rare case of lung cancer with the simultaneous production of granulocyte colony-stimulating factor (G-CSF) and interleukin-6 (IL-6) is reported. A 79-year-old man was admitted to our hospital due to cachectic symptoms and an increased inflammatory response. Laboratory tests and imaging studies suggested metastatic lung cancer with high serum levels of G-CSF and IL-6. He died of progressive disease, and an autopsy showed that the lung tumor had positive protein expression of both cytokines and a solid growth of large-cell carcinoma with sarcomatoid changes, possibly resulting from the epithelial-mesenchymal transition mediated by IL-6 and leading to widespread metastases.

摘要

报告了一例罕见的同时产生粒细胞集落刺激因子（G-CSF）和白细胞介素-6（IL-6）的肺癌病例。一名79岁男性因恶病质症状和炎症反应增强入住我院。实验室检查和影像学研究提示为转移性肺癌，血清G-CSF和IL-6水平升高。他死于疾病进展，尸检显示肺肿瘤这两种细胞因子的蛋白表达均为阳性，且为具有肉瘤样改变的大细胞癌实体生长，可能是由IL-6介导的上皮-间质转化所致，并导致广泛转移。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fc5a/6911748/4f73abfc27b5/1349-7235-58-3305-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fc5a/6911748/2ff7ff38ee0a/1349-7235-58-3305-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fc5a/6911748/3f13d4431e89/1349-7235-58-3305-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fc5a/6911748/0b45bc8d44eb/1349-7235-58-3305-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fc5a/6911748/994522d4b940/1349-7235-58-3305-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fc5a/6911748/4f73abfc27b5/1349-7235-58-3305-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fc5a/6911748/2ff7ff38ee0a/1349-7235-58-3305-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fc5a/6911748/3f13d4431e89/1349-7235-58-3305-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fc5a/6911748/0b45bc8d44eb/1349-7235-58-3305-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fc5a/6911748/994522d4b940/1349-7235-58-3305-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fc5a/6911748/4f73abfc27b5/1349-7235-58-3305-g005.jpg

相似文献

1
Granulocyte Colony-stimulating Factor- and Interleukin-6-producing Large-cell Carcinoma of the Lung with Sarcomatoid Changes Suggestive of Epithelial-mesenchymal Transition: An Autopsy Case Report.伴有提示上皮-间质转化的肉瘤样改变的粒细胞集落刺激因子和白细胞介素-6分泌性肺大细胞癌：一例尸检病例报告
Intern Med. 2019 Nov 15;58(22):3305-3311. doi: 10.2169/internalmedicine.2819-19. Epub 2019 Jul 31.
2
[Granulocyte colony-stimulating factor producing lung large cell carcinoma with sarcomatous transformation].[伴有肉瘤样转化的粒细胞集落刺激因子产生性肺大细胞癌]
Nihon Kyobu Shikkan Gakkai Zasshi. 1992 Aug;30(8):1548-53.
3
Effect of serum deprivation on constitutive production of granulocyte-colony stimulating factor and granulocyte macrophage-colony stimulating factor in lung cancer cells.血清剥夺对肺癌细胞中粒细胞集落刺激因子和粒细胞巨噬细胞集落刺激因子组成性产生的影响。
Int J Cancer. 2004 May 10;109(6):826-32. doi: 10.1002/ijc.20023.
4
A case of granulocyte colony-stimulating factor-producing intrahepatic sarcomatoid cholangiocarcinoma.粒细胞集落刺激因子产生的肝内肉瘤样胆管细胞癌 1 例。
Clin J Gastroenterol. 2021 Jun;14(3):881-887. doi: 10.1007/s12328-021-01405-7. Epub 2021 Mar 30.
5
[Granulocyte-colony stimulating factor producing tumor with high serum interleukin-6].[产生粒细胞集落刺激因子的肿瘤伴血清白细胞介素-6升高]
Kyobu Geka. 2008 Nov;61(12):1049-52.
6
A case of primary lung squamous cell carcinoma mimicking malignant mesothelioma producing granulocyte colony stimulating factor with chemotherapy (cisplatin and gemcitabine)-associated thrombotic thrombocytopenic purpura (TTP); An autopsy case report.一例原发性肺鳞癌模拟恶性间皮瘤产生粒细胞集落刺激因子伴化疗（顺铂和吉西他滨）相关血栓性血小板减少性紫癜（TTP）；尸检病例报告。
Lung Cancer. 2019 Oct;136:105-108. doi: 10.1016/j.lungcan.2019.08.018. Epub 2019 Aug 20.
7
Lung large cell carcinoma producing granulocyte-colony-stimulating factor.产生粒细胞集落刺激因子的肺大细胞癌
Ann Thorac Surg. 2007 Jan;83(1):308-10. doi: 10.1016/j.athoracsur.2006.04.049.
8
Establishment of a large cell lung cancer cell line (Y-ML-1B) producing granulocyte colony-stimulating factor.
Cancer Genet Cytogenet. 2002 Aug;137(1):33-42. doi: 10.1016/s0165-4608(02)00536-8.
9
[Expression of granulocyte colony stimulating factor in patients with non-small cell lung cancer and its clinicopathological significance].
Zhonghua Bing Li Xue Za Zhi. 2011 Nov;40(11):721-5.
10
Colony-stimulating factor-producing tumours: production of granulocyte colony-stimulating factor and interleukin-6 is secondary to interleukin-1 production.
Eur J Cancer. 1994;30A(14):2130-6. doi: 10.1016/0959-8049(94)00347-8.

引用本文的文献

1
Programmed cell death ligand 1 measurement study in granulocyte colony-stimulating factor-producing lung cancer: an observational study.程序性细胞死亡配体 1 测量在粒细胞集落刺激因子产生的肺癌中的研究：一项观察性研究。
BMC Cancer. 2022 Sep 13;22(1):977. doi: 10.1186/s12885-022-10065-w.
2
G-CSF in tumors: Aggressiveness, tumor microenvironment and immune cell regulation.G-CSF 与肿瘤：侵袭性、肿瘤微环境与免疫细胞调控。
Cytokine. 2021 Jun;142:155479. doi: 10.1016/j.cyto.2021.155479. Epub 2021 Mar 4.
3
Discovery of core gene families associated with liver metastasis in colorectal cancer and regulatory roles in tumor cell immune infiltration.

本文引用的文献

1
Esophageal Carcinosarcoma that Was Diagnosed as a Granulocyte-colony Stimulating Factor and Interleukin-6-producing Tumor with a Tumor Fever.被诊断为产生粒细胞集落刺激因子和白细胞介素-6并伴有肿瘤热的食管癌肉瘤
Intern Med. 2018 Oct 1;57(19):2819-2825. doi: 10.2169/internalmedicine.0677-17. Epub 2018 May 18.
2
Granulocyte colony stimulating factor-producing lung cancer with severe anemia of inflammation.产生粒细胞集落刺激因子的肺癌伴严重炎症性贫血
Gen Thorac Cardiovasc Surg. 2018 Jul;66(7):415-418. doi: 10.1007/s11748-018-0914-1. Epub 2018 Mar 28.
3
Interleukin-6 blockade attenuates lung cancer tissue construction integrated by cancer stem cells.
结直肠癌肝转移相关核心基因家族的发现及其在肿瘤细胞免疫浸润中的调控作用。
Transl Oncol. 2021 Mar;14(3):101011. doi: 10.1016/j.tranon.2021.101011. Epub 2021 Jan 13.
4
Pulmonary sarcomatoid carcinoma: progress, treatment and expectations.肺肉瘤样癌：进展、治疗与展望。
Ther Adv Med Oncol. 2020 Aug 25;12:1758835920950207. doi: 10.1177/1758835920950207. eCollection 2020.
白细胞介素-6 阻断削弱了由肿瘤干细胞整合构建的肺癌组织。
Sci Rep. 2017 Sep 26;7(1):12317. doi: 10.1038/s41598-017-12017-y.
4
Tracking the Evolution of Non-Small-Cell Lung Cancer.跟踪非小细胞肺癌的演变。
N Engl J Med. 2017 Jun 1;376(22):2109-2121. doi: 10.1056/NEJMoa1616288. Epub 2017 Apr 26.
5
IL-6 promotes growth and epithelial-mesenchymal transition of CD133+ cells of non-small cell lung cancer.白细胞介素-6促进非小细胞肺癌CD133+细胞的生长和上皮-间质转化。
Oncotarget. 2016 Feb 9;7(6):6626-38. doi: 10.18632/oncotarget.6570.
6
IL-6 signaling contributes to cisplatin resistance in non-small cell lung cancer via the up-regulation of anti-apoptotic and DNA repair associated molecules.白细胞介素-6信号传导通过上调抗凋亡和DNA修复相关分子，促进非小细胞肺癌对顺铂的耐药性。
Oncotarget. 2015 Sep 29;6(29):27651-60. doi: 10.18632/oncotarget.4753.
7
Granulocyte colony-stimulating factor-producing carcinoma of unknown primary site.原发部位不明的粒细胞集落刺激因子产生性癌
Case Rep Oncol. 2014 Nov 22;7(3):780-8. doi: 10.1159/000369335. eCollection 2014 Sep-Dec.
8
A pleomorphic carcinoma of the lung producing multiple cytokines and forming a rapidly progressive mass-like opacity.一种产生多种细胞因子并形成快速进展的肿块样混浊的肺多形性癌。
BMC Cancer. 2014 Aug 13;14:588. doi: 10.1186/1471-2407-14-588.
9
Tocilizumab, a proposed therapy for the cachexia of Interleukin6-expressing lung cancer.托珠单抗，一种针对表达白细胞介素6的肺癌恶病质的拟用疗法。
PLoS One. 2014 Jul 10;9(7):e102436. doi: 10.1371/journal.pone.0102436. eCollection 2014.
10
IL-6 enriched lung cancer stem-like cell population by inhibition of cell cycle regulators via DNMT1 upregulation.白细胞介素-6通过上调DNA甲基转移酶1抑制细胞周期调节因子，从而富集肺癌干细胞样细胞群体。
Int J Cancer. 2015 Feb 1;136(3):547-59. doi: 10.1002/ijc.29033. Epub 2014 Jun 27.