Markov Kh M
Kardiologiia. 1989 Sep;29(9):5-12.
The paper considers the significance of prostacyclin-thromboxane (PGI2/TxA2) balance for cardiovascular performance in health and in angina pectoris and myocardial infarction. The functional interaction between prostacyclin and thromboxane was examined in terms of a number of risk factors for coronary heart disease (CHD), such as ageing, atherosclerosis, arterial hypertension, diabetes mellitus, obesity, hypokinesia, smoking, alcoholism, sex differences, and predisposition to the disease. A unidirectional pattern of changes in the PGI2/TxA2 balance towards TxA2 was found in CHD and in the presence of all the aforementioned risk factors. The paper discusses possible mechanisms responsible for these changes, as well as their contribution to the pathogenesis and prevention of CHD.
本文探讨了前列环素-血栓素（PGI2/TxA2）平衡对健康人群以及心绞痛和心肌梗死患者心血管功能的重要性。从冠心病（CHD）的一些危险因素，如衰老、动脉粥样硬化、动脉高血压、糖尿病、肥胖、运动不足、吸烟、酗酒、性别差异和疾病易感性等方面，研究了前列环素与血栓素之间的功能相互作用。在冠心病以及存在所有上述危险因素的情况下，发现PGI2/TxA2平衡向血栓素方向呈单向变化模式。本文讨论了这些变化可能的机制，以及它们对冠心病发病机制和预防的作用。
