Spyropoulou G A, Pavlidis L, Trakatelli M, Athanasiou E, Pazarli E, Sotiriadis D, Demiri E
Department of Plastic and Reconstructive Surgery, Aristotle University of Thessaloniki, Papageorgiou General Hospital, Thessaloniki, Greece.
J Eur Acad Dermatol Venereol. 2015 Jan;29(1):7-13. doi: 10.1111/jdv.12623. Epub 2014 Aug 14.
Benign lesions of the breast in total are much more frequent than malignant ones. However, there are no epidemiologic data on the prevalence of benign or malignant tumours of the nipple, and the bibliography on benign nipple tumours in general is limited.
To present some rare cases of benign nipple tumours and review the literature.
Four cases of rare benign nipple tumours: neurofibromas, wart, leiomyoma and milium are presented. The literature search on benign nipple tumours was performed using MEDLINE, Pubmed, and Cochrane databases with limits: English language, human species and available abstract. The keyword used was 'benign nipple tumours'.
The initial search retrieved 337 articles. The papers were reviewed and the articles that referred to benign lesions that appeared at the nipple specifically were identified. Different entities that were described included: neurofibroma, leiomyoma, milium, florid papillomatosis, syringomatous adenoma, nevoid hyperkeratosis, fibroma, pseudolymphoma and haemangioma.
Differential diagnosis of benign tumours of the nipple can be demanding for the physicians. Many of the symptoms and signs like pruritus, serosanguinous discharge, lichenification, erosion and nodular enlargement are produced by either malignant or benign nipple lesions. Radiology can be unclear in the diagnosis of nipple abnormalities.
Histological examination of the lesion can be the only definite answer in these cases.
乳腺良性病变总体上比恶性病变更为常见。然而，目前尚无关于乳头良性或恶性肿瘤患病率的流行病学数据，而且关于乳头良性肿瘤的文献总体有限。
介绍一些罕见的乳头良性肿瘤病例并复习文献。
介绍4例罕见的乳头良性肿瘤：神经纤维瘤、疣、平滑肌瘤和粟丘疹。使用MEDLINE、Pubmed和Cochrane数据库对乳头良性肿瘤进行文献检索，检索限制为：英文文献、人类文献及可获取摘要。使用的关键词为“乳头良性肿瘤”。
初步检索获得337篇文章。对这些文章进行了综述，并确定了专门提及乳头出现的良性病变的文章。所描述的不同病变包括：神经纤维瘤、平滑肌瘤、粟丘疹、 florid乳头瘤病、汗腺腺瘤、痣样角化过度、纤维瘤、假性淋巴瘤和血管瘤。
乳头良性肿瘤的鉴别诊断对医生来说可能具有挑战性。许多症状和体征，如瘙痒、浆液性血性溢液、苔藓样变、糜烂和结节性增大，可由恶性或良性乳头病变引起。影像学检查在乳头异常的诊断中可能不明确。
在这些病例中，病变的组织学检查可能是唯一明确的答案。
