Doctor V M, Sirsat M V
Br J Cancer. 1971 Mar;25(1):1-9. doi: 10.1038/bjc.1971.1.
The paper deals with 20 benign tumours of the nipple and areola. The most common lesion was adenoma or florid papillomatosis (11 cases). On the basis of clinical and histological differences, the cases were divided into two groups.Group I.-Tumours showing an adenomatous pattern (5 cases) appropriately termed adenoma of the nipple. Chief clinical features were younger age, long duration and enlargement of the nipple as a predominant symptom. Histological characteristics were elongated tubules separated by a varying amount of fibrous stroma and squamous metaplasia in some of the cases.Group II.-Tumours showing a papillomatous pattern (6 cases) appropriately designated as florid papillomatosis. Clinically, the patients were older. Chief complaint was bleeding from the nipple of a few months' duration. Histologically, dilated lactiferous ducts were seen filled with papillary, cribriform and solid growth of cells. Other features such as apocrine metaplasia, foam cells and central necrosis were observed.The interpretation of this grouping is discussed.A case of adenoma of an accessory nipple is reported.Other benign tumours observed were five papillomas, one leiomyoma, one haemangioma, one fibroma and one lipoma.
本文探讨了20例乳头和乳晕的良性肿瘤。最常见的病变是腺瘤或富于细胞的乳头状瘤病(11例)。根据临床和组织学差异,将病例分为两组。第一组:表现为腺瘤样模式的肿瘤(5例),恰当地称为乳头腺瘤。主要临床特征为年龄较轻、病程长,以乳头增大为主要症状。组织学特征为细长的小管,被不同量的纤维性间质分隔,部分病例可见鳞状化生。第二组:表现为乳头状模式的肿瘤(6例),恰当地称为富于细胞的乳头状瘤病。临床上,患者年龄较大。主要症状为持续数月的乳头出血。组织学上,可见扩张的输乳管内充满乳头状、筛状和实性细胞生长。还观察到其他特征,如大汗腺化生、泡沫细胞和中央坏死。对这种分组的解释进行了讨论。报告了1例副乳头腺瘤病例。观察到的其他良性肿瘤包括5例乳头状瘤、1例平滑肌瘤、1例血管瘤、1例纤维瘤和1例脂肪瘤。