Liu Qing, Yin Zheng-Qin, Ke Ning, Chen Lin, Chen Xin-Ke, Fang Jing, Chen Xiu-Rong, Xiao Jun, Hu Kang, Zhang Xuan, Xiong Yan, Shi Hui, Li Jie, Long Hong-Jian, Zhang Kang-Lin, Chen Zhi-Yu, Pi Lian-Hong
Department of Ophthalmology, Children's Hospital, Chongqing Medical University, Chongqing, China (mainland).
Department of Ophthalmology, Southwest Hospital, Third Military Medical University, Chongqing, China (mainland).
Med Sci Monit. 2014 Aug 15;20:1442-51. doi: 10.12659/MSM.890688.
The aim of this study was to screen for retinopathy of prematurity (ROP) in southwestern China and understand the prevalence and risk factors of ROP, which may provide evidence useful in the prevention and treatment of ROP.
MATERIAL/METHODS: 1864 preterm infants (gestational age of <37 weeks and birth weight of ≤2500 g) underwent ROP screening from January 2009 to November 2012 in Southwest China. The medical information of infants during perinatal period was reviewed, and risk factors of ROP were determined. A total of 1614 infants were recruited for final analysis.
Incidence of ROP was 12.8%. The first, second, third, and fourth stage of ROP was found in 64.6%, 29.6%, 3.4%, and 0.5% of infants, respectively. No fifth stage of ROP was observed. In addition, 7.7% of infants required surgical intervention. In our Department of Neonatology, the incidence of ROP was 20.0%, which was significantly higher than in non-hospitalized patients (9.9%). The incidence of ROP remained unchanged over the years. Independent risk factors of ROP included low birth weight (p=0.049), low gestational age (p=0.008), days of oxygen supplementation (p=0.008), and myocardial injury after birth (p=0.001).
The prevalence of ROP in preterm infants is relatively high in Southwest China, and low birth weight, low gestational age, days of oxygen supplementation, and myocardial injury after birth are independent risk factors for ROP.
本研究旨在对中国西南部地区的早产儿视网膜病变（ROP）进行筛查，并了解ROP的患病率及危险因素，为ROP的防治提供依据。
材料/方法：2009年1月至2012年11月期间，对中国西南部地区1864例早产儿（胎龄<37周，出生体重≤2500g）进行了ROP筛查。回顾了婴儿围生期的医学信息，确定了ROP的危险因素。最终纳入1614例婴儿进行分析。
ROP发病率为12.8%。ROP一期、二期、三期和四期分别在64.6%、29.6%、3.4%和0.5%的婴儿中发现。未观察到ROP五期。此外，7.7%的婴儿需要手术干预。在我院新生儿科，ROP发病率为20.0%，显著高于非住院患儿（9.9%）。多年来ROP发病率保持不变。ROP的独立危险因素包括低出生体重（p=0.049）、低胎龄（p=0.008）、吸氧天数（p=0.008）和出生后心肌损伤（p=0.001）。
中国西南部地区早产儿ROP患病率较高，低出生体重、低胎龄、吸氧天数和出生后心肌损伤是ROP的独立危险因素。
