伊朗早产儿视网膜病变的患病率及危险因素
Prevalence and Risk Factors of Retinopathy of Prematurity in Iran.
作者信息
Zarei Mohammad, Bazvand Fatemeh, Ebrahimiadib Nazanin, Roohipoor Ramak, Karkhaneh Reza, Farahani Dastjani Afsar, Imani Fouladi Marjan, Riazi Esfahani Mohammad, Khodabande Alireza, Davoudi Samaneh, Ghasemi Hamed, S Modjtahedi Bobeck
机构信息
Eye Research Center, Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Department of Ophthalmology, Gavin Herbert Eye Institute, University of California, Irvine, CA, USA.
出版信息
J Ophthalmic Vis Res. 2019 Jul 18;14(3):291-298. doi: 10.18502/jovr.v14i3.4785. eCollection 2019 Jul-Sep.
PURPOSE
The present study aimed to evaluate the frequency and risk factors of retinopathy of prematurity (ROP) among Iranian infants.
METHODS
A retrospective cohort study was conducted on infants who had undergone screening for ROP at Farabi Eye Hospital, between March 2016 and March 2017. Data were analyzed based on the presence of extreme prematurity (gestational age 28 weeks), extremely low-birth-weight ( 1000 g), and multiple-gestation (MG) infants.
RESULTS
The prevalence of ROP was 27.28% ( = 543) among all screened infants, 74.4% for extremely preterm (EP) infants, 77.5% for extremely low birth weight (ELBW) babies, and 27.25% for infants from MG pregnancies. On multivariate analysis, gestational age, birth weight, and history of transfusion ( < 0.0001, < 0.0001, and = 0.04, respectively) were found to be significantly associated with ROP. More advanced stages of ROP ( < 0.0001) were observed in EP and ELBW infants. Birth weight ( = 0.088), history of transfusion ( = 0.066), and intubation ( = 0.053) were not associated with increased risk of ROP in EP infants, while gestational age ( = 0.037) and history of transfusion ( = 0.040) were significant risk factors for ROP in ELBW infants. Gestational age (P < 0.001) and birth weight ( = 0.001) were significantly associated with ROP in infants from MG pregnancies in multivariate analysis.
CONCLUSION
ROP remains a commonly encountered disease, especially in ELBW and EP infants. The history of transfusion may have a role in stratifying the risk for ROP and guiding future screening guidelines.
目的
本研究旨在评估伊朗婴儿中早产儿视网膜病变（ROP）的发生率及危险因素。
方法
对2016年3月至2017年3月在法拉比眼科医院接受ROP筛查的婴儿进行回顾性队列研究。基于极早产儿（胎龄<28周）、极低出生体重儿（<1000g）和多胎妊娠（MG）婴儿的情况对数据进行分析。
结果
在所有接受筛查的婴儿中，ROP的患病率为27.28%（n = 543），极早产儿（EP）中为74.4%，极低出生体重儿（ELBW）中为77.5%，多胎妊娠婴儿中为27.25%。多因素分析发现，胎龄、出生体重和输血史（分别为P<0.0001、P<0.0001和P = 0.04）与ROP显著相关。在EP和ELBW婴儿中观察到ROP更晚期阶段（P<0.0001）。出生体重（P = 0.088）、输血史（P = 0.066）和插管（P = 0.053）与EP婴儿ROP风险增加无关，而胎龄（P = 0.037）和输血史（P = 0.040）是ELBW婴儿ROP的显著危险因素。多因素分析中，胎龄（P<0.001）和出生体重（P = 0.001）与多胎妊娠婴儿的ROP显著相关。
结论
ROP仍然是一种常见疾病，尤其是在ELBW和EP婴儿中。输血史可能在分层ROP风险和指导未来筛查指南方面发挥作用。
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