补骨脂中的杂萜类化合物对稻瘟病菌的作用
Meroterpenes from Psoralea corylifolia against Pyricularia oryzae.
作者信息
Huang Youwu, Liu Xiaoyu, Wu Yingchun, Li Yiming, Guo Fujiang
机构信息
School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, P. R. China.
Department of Biological Chemistry, Second Military Medicinal University, Shanghai, P. R. China.
出版信息
Planta Med. 2014 Oct;80(15):1298-303. doi: 10.1055/s-0034-1382995. Epub 2014 Aug 15.
Six new meroterpenes, namely, 13-methoxyisobakuchiol (1), 13-ethoxyisobakuchiol (2), 12,13-dihydro-13-hydroxybakuchiol (3), Δ(10)-12,13-dihydro-12-(R,S)-methoxyisobakuchiol (4 and 5), and 15-demetyl-12,13-dihydro-13-ketobakuchiol (6), together with four known ones, namely, Δ(3),2-hydroxybakuchiol (7), Δ(1),3-hydroxybakuchiol (8), bakuchiol (9), and Δ(1,3)-bakuchiol (10), were isolated from the seeds of Psoralea corylifolia. Their structures were identified based on spectral data, including those obtained via 1D and 2D NMR, and MS spectral analyses. Antifungal screening results indicated that all compounds showed moderate inhibitory activities against Pyricularia oryzae.
从补骨脂种子中分离出6个新的半萜，即13-甲氧基异补骨脂酚（1）、13-乙氧基异补骨脂酚（2）、12,13-二氢-13-羟基补骨脂酚（3）、Δ(10)-12,13-二氢-12-(R,S)-甲氧基异补骨脂酚（4和5）以及15-去甲基-12,13-二氢-13-氧代补骨脂酚（6），同时还分离出4个已知化合物，即Δ(3),2-羟基补骨脂酚（7）、Δ(1),3-羟基补骨脂酚（8）、补骨脂酚（9）和Δ(1,3)-补骨脂酚（10）。基于光谱数据，包括通过一维和二维核磁共振以及质谱光谱分析获得的数据，确定了它们的结构。抗真菌筛选结果表明，所有化合物对稻瘟病菌均表现出中等抑制活性。
Zotero 插件