Key Laboratory of Standardization of Chinese Medicines of Ministry of Education, The Shanghai Key Laboratory for Compound Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
Fitoterapia. 2012 Dec;83(8):1553-7. doi: 10.1016/j.fitote.2012.08.024. Epub 2012 Sep 6.
A new meroterpene, psoracorylifol F (1), was isolated from Psoralea corylifolia fruits, along with two known meroterpenes (2 and 3), guided by TLC bioautography against O(2)(-) radicals. The structure of 1 was elucidated by means of NMR, HRESIMS, and X-ray crystallographic analysis. All the three metroterpenes possessed potential inhibitory activity against LPS-induced NO production in RAW 264.7 cells with IC(50) values ranging from 7.71 to 27.63μM.
从补骨脂果实中分离得到一个新的倍半萜类化合物，psoracorylifol F（1），并通过 TLC 生物自显影法对抗 O(2)(-)自由基，从补骨脂中分离得到两个已知的倍半萜类化合物（2 和 3）。通过 NMR、HRESIMS 和 X 射线晶体学分析阐明了 1 的结构。所有三种代谢萜类化合物均具有潜在的抑制 LPS 诱导的 RAW 264.7 细胞中 NO 产生的活性，IC(50)值范围为 7.71 至 27.63μM。
