Brown J N W, Robertson J D, Brockman J D
Department of Chemistry, University of Missouri, Columbia, MO 65211, United States.
Department of Chemistry, University of Missouri, Columbia, MO 65211, United States; Research Reactor, University of Missouri, Columbia, MO 65211, United States.
Talanta. 2014 Nov;129:481-5. doi: 10.1016/j.talanta.2014.06.015. Epub 2014 Jun 18.
A bioassay capable of monitoring occupational or environmental exposure to special nuclear materials would be a useful tool for nuclear nonproliferation programs. Hair and nail are potential biomonitors of exposure to U and Pu. A method is described to measure isotope ratios of ultra-trace concentrations of U and Pu in hair and nail samples. The method uses multiple extraction chromatography resins to separate U and Pu fractions from the sample matrix. The U recovery was quantitative while the Pu recovery ranged from 81% to 109%, with a U decontamination factor of 5×10(4). Following the separation (234)U/(238)U, (235)U/(238)U and (240)Pu/(239)Pu were measured in human hair and hair and nail samples using multi-collector inductively coupled plasma mass spectrometry (MC-ICPMS). The human hair and nail samples had elevated ratios of (234)U/(238)U which could reflect exposure to naturally fractionated U.
一种能够监测职业或环境中特殊核材料暴露情况的生物测定法，对核不扩散计划而言将是一种有用的工具。头发和指甲是暴露于铀和钚的潜在生物监测指标。本文描述了一种测量头发和指甲样本中痕量铀和钚同位素比值的方法。该方法使用多种萃取色谱树脂从样品基质中分离铀和钚组分。铀的回收率是定量的，而钚的回收率在81%至109%之间，铀的去污系数为5×10⁴。分离后，使用多接收电感耦合等离子体质谱法（MC-ICPMS）测量人发以及头发和指甲样本中的²³⁴U/²³⁸U、²³⁵U/²³⁸U和²⁴⁰Pu/²³⁹Pu比值。人发和指甲样本的²³⁴U/²³⁸U比值升高，这可能反映了对天然分馏铀的暴露。
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