Li Gang, Shi Fengjun, Liu Jingchen, Li Ye
Department of Orthopaedics, Daqing General Hospital Group Oilfield General Hospital, Daqing 163001, China.
Diagn Pathol. 2014 Aug 16;9:157. doi: 10.1186/s13000-014-0157-0.
Recently, a number of studies have been performed to explore the association between CTLA-4 A49G polymorphism and rheumatoid arthritis (RA). However, the results of previous works are still controversial and ambiguous.
In this work, we attempted to perform an updated meta-analysis of available case-control study in order to assess the association between CTLA-4 A49G polymorphism and RA risk. We searched the various citation databases without limits on languages. Article searching was performed by screening the references of retrieved studies manually. Odds ratios (OR) and 95% confidence intervals (95% CI) were calculated to evaluate the strength of the association.
We totally compiled 27 studies in 24 articles (9805 RA patients and 10691 control subjects) into our meta-analysis work. We found significant association between CTL-A4 A49G polymorphism and RA risk (GG vs. AA: OR = 1.13, 95% CI = 1.03-1.23; GA vs. AA: OR = 1.19, 95% CI = 1.07-1.33; GA + GG vs. AA: OR = 1.18, 95% CI = 1.07-1.29). In the subgroup analysis by ethnicity, evidences of significantly increased risk was also found in both Asian (GG vs. AA: OR = 1.34, 95% CI = 1.15-1.55; GA + GG vs. AA: OR = 1.24, 95% CI = 1.08-1.41) and Caucasian population (GA vs. AA: OR = 1.19, 95% CI = 1.03-1.37; GA + GG vs. AA: OR = 1.14, 95% CI = 1.01-1.29). No evidence of publication bias was found in this work.
Our meta-analysis suggests that CTLA-4 A49G polymorphism was associated with RA risk.
The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/13000_2014_157.
最近，已经开展了多项研究来探索细胞毒性T淋巴细胞相关抗原4（CTLA-4）A49G多态性与类风湿关节炎（RA）之间的关联。然而，先前研究的结果仍存在争议且不明确。
在本研究中，我们试图对现有的病例对照研究进行更新的荟萃分析，以评估CTLA-4 A49G多态性与RA风险之间的关联。我们搜索了各种文献数据库，没有语言限制。通过手动筛选检索到的研究的参考文献来进行文献搜索。计算比值比（OR）和95%置信区间（95%CI）以评估关联强度。
我们总共将24篇文章中的27项研究（9805例RA患者和10691例对照受试者）纳入我们的荟萃分析工作。我们发现CTL-A4 A49G多态性与RA风险之间存在显著关联（GG与AA比较：OR = 1.13，95%CI = 1.03 - 1.23；GA与AA比较：OR = 1.19，95%CI = 1.07 - 1.33；GA + GG与AA比较：OR = 1.18，95%CI = 1.07 - 1.29）。在按种族进行的亚组分析中，在亚洲人群（GG与AA比较：OR = 1.34，95%CI = 1.15 - 1.55；GA + GG与AA比较：OR = 1.24，95%CI = 1.08 - 1.41）和白种人群（GA与AA比较：OR = 1.19，95%CI = 1.03 - 1.37；GA + GG与AA比较：OR = 1.14，95%CI = 1.01 - 1.29）中也发现了风险显著增加的证据。在本研究中未发现发表偏倚的证据。
我们的荟萃分析表明，CTLA-4 A49G多态性与RA风险相关。
本文的虚拟切片可在此处找到：http://www.diagnosticpathology.diagnomx.eu/vs/13000_2014_157 。
