Sankhyan Naveen, Saptharishi L G, Sasidaran Kandasamy, Kanga Anil, Singhi Sunit C
Department of Pediatrics, PGIMER, Chandigarh; and *Department of Microbiology, Indira Gandhi Medical College, Shimla, India. Correspondence to: Prof. Sunit C Singhi, Professor and Head, Department of Pediatrics, Advanced Pediatric Centre, Post Graduate Institute of Medical Education and Research, Chandigarh 160 012, India.
Indian Pediatr. 2014 Aug;51(8):651-3. doi: 10.1007/s13312-014-0470-4.
To study the clinical profile of children with scrub typhus and its association with hemophagocytic lymphohistiocytosis.
Children presenting with unexplained fever and multi-systemic involvement between May to December 2011 were tested for scrub typhus using IgM ELISA kits. Occurrence of Hemophagocytic lymphohistiocytosis in IgM positive cases of scrub typhus was studied.
Of the 35 children with unexplained fever and multi-systemic involvement, 15 children (9 boys) tested positive for scrub typhus. Thrombocytopenia, hypoalbuminemia and raised hepatic transaminases were observed in all children. Out of seven children evaluated for hemophagocytic lymphohistiocytosis. 3 met the criteria for hemophagocytosis. Two children (one with hemophagocytic lymphohistiocytosis) died.
Scrub typhus is a common cause of unexplained fever in children in northern India. Hemophagocytic lymphohistiocytosis can occasionally complicate scrub typhus in children.
研究恙虫病患儿的临床特征及其与噬血细胞性淋巴组织细胞增生症的关联。
对2011年5月至12月出现不明原因发热及多系统受累的儿童，使用IgM酶联免疫吸附测定试剂盒检测恙虫病。研究恙虫病IgM阳性病例中噬血细胞性淋巴组织细胞增生症的发生情况。
在35例不明原因发热及多系统受累的儿童中，15例（9例男孩）恙虫病检测呈阳性。所有儿童均观察到血小板减少、低白蛋白血症及肝转氨酶升高。在评估的7例噬血细胞性淋巴组织细胞增生症患儿中，3例符合噬血细胞形成标准。2例患儿（1例患有噬血细胞性淋巴组织细胞增生症）死亡。
恙虫病是印度北部儿童不明原因发热的常见病因。噬血细胞性淋巴组织细胞增生症偶尔会使儿童恙虫病复杂化。
